Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis

British Journal of Cancer
Elin Hadler-Olsen, Anna Maria Wirsing

Abstract

Various immune cells have been suggested as prognostic markers for cancer patients. In this article, we present a systematic review and meta-analysis of studies assessing the prognostic value of tissue-infiltrating immune cells in oral cancer and discuss the reporting quality of these studies. We performed a systematic literature search and included studies using immunohistochemistry and survival analysis to assess the prognostic value of tumour-infiltrating T cells, B cells, macrophages, dendritic cells, mast cells and natural killer cells in oral cancer. We performed meta-analysis of studies providing necessary statistical data and investigated the studies' adherence to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guidelines. Of the 1960 articles identified, 33 were eligible for this systematic review and 8 were included in the meta-analysis. CD163+ M2 macrophages and CD57+ natural killer cells were the most promising predictors of survival in oral cancer patients. Many studies lacked important information on their design and conduct. Deficiencies in the reporting of study design and conduct make it difficult to draw reliable conclusions about the suggested markers. The prognostic value of CD163...Continue Reading

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Citations

Jul 20, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhengxian HuangCheng Wang
Jul 1, 2020·Current Oncology Reports·Niels E WondergemRieneke van de Ven
Jul 8, 2020·Cancers·Faustino J Suárez-SánchezJuan C de Vicente
Sep 23, 2020·Head and Neck Pathology·Meri SieviläinenAhmed Al-Samadi
Apr 28, 2020·Laryngoscope Investigative Otolaryngology·Hassan Nasser, Maie A St John
Dec 22, 2020·Journal of Oral Biology and Craniofacial Research·Nilookumari ChoudharyShankargouda Patil
Jan 23, 2021·Frontiers in Oncology·Yuehong CuiTianshu Liu
Jan 27, 2021·Cancers·Faustino Julián Suárez-SánchezJuan Carlos de Vicente
May 24, 2020·Oral Oncology·Alhadi AlmangushIlmo Leivo
Mar 7, 2021·International Journal of Molecular Sciences·Hui-Ching WangMei-Ren Pan
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Raísa Sales de SáLuiz Paulo Kowalski
Mar 26, 2021·Frontiers in Oncology·Alhadi AlmangushAntti A Mäkitie
May 25, 2021·Molecular Therapy Oncolytics·Guangshun SunYangbai Sun
Aug 28, 2021·Cancers·Giovanni Nicolao BertaBarbara Mognetti

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Methods Mentioned

BETA
biopsy

Software Mentioned

Ovid
Review Manager ( RevMan )

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