Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction

American Heart Journal
Erdal CavusogluJonathan D Marmur

Abstract

Matrix metalloproteinases and their inhibitors have been implicated in both vascular and ventricular remodeling, and in atherosclerotic plaque rupture. The prognostic value of plasma tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in patients with established or suspected coronary artery disease is unknown. Tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9 (MMP-9) levels, along with a number of other established biomarkers, were measured in 389 male patients undergoing coronary angiography at a Veterans Administration Medical Center. The patients were then followed prospectively for the occurrence of all-cause mortality, cardiac mortality, and myocardial infarction (MI). Follow-up data at 24 months were available for 97% of the patients. For the entire cohort of patients, TIMP-1 was the only biomarker to independently predict all-cause mortality and MI. In addition, the ratio of TIMP-1 to matrix metalloproteinase-9 was independently predictive of cardiac mortality at 24 months. The 24-month survival rates for patients in the lower quartile (< 66.5 ng/mL), interquartile (66.5-100 ng/mL), and upper quartile (> 100 ng/mL) of plasma TIMP-1 values were 95.3%, 89.3%, and 72.2%, respectively (P < .001). Fu...Continue Reading

References

Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Mar 10, 2000·Biochimica Et Biophysica Acta·K BrewH Nagase
Oct 31, 2003·Expert Reviews in Molecular Medicine·Marc A LafleurDylan R Edwards
Oct 7, 2004·Biochemical and Biophysical Research Communications·Takemi AkahaneUnnur P Thorgeirsson

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Citations

Jul 16, 2008·Current Atherosclerosis Reports·Anand Prasad, Sotirios Tsimikas
Aug 21, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Rugmani Padmanabhan IyerMerry L Lindsey
Aug 28, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Raghava S VelagaletiRamachandran S Vasan
May 3, 2013·PloS One·Nilminie RathnayakeAnders Gustafsson
Apr 15, 2014·PloS One·Leonardo LorenteJosé A Páramo
Nov 26, 2010·Journal of Periodontology·Eralp BuduneliTimo Sorsa
May 3, 2013·Journal of Periodontology·Francesco D'AiutoJohn C Gunsolley
Nov 9, 2012·Neurology India·Subhash Kaul, Anjana Munshi
May 2, 2014·Biochemical Pharmacology·Francis G Spinale, Francisco Villarreal
Oct 20, 2014·Current Cardiology Reports·P K Shah
Oct 20, 2011·British Medical Bulletin·Mohammad Madjid, James T Willerson
Mar 13, 2012·Heart Failure Clinics·Viorel G Florea, Inder S Anand
Jun 29, 2010·International Journal of Cardiology·Nitin MahajanSanjay Jain
May 25, 2010·International Journal of Cardiology·Cord ManhenkeKenneth Dickstein
Mar 5, 2016·Journal of Internal Medicine·M LynchM Mayr
Dec 3, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yuko AbeKazuo Kitagawa
Jul 29, 2008·International Journal of Cardiology·Jessica M LambertMerry L Lindsey
May 22, 2007·Metabolism: Clinical and Experimental·Barbara Głowińska-Olszewska, Mirosława Urban
Jan 16, 2007·Atherosclerosis·Konstantinos AznaouridisChristodoulos Stefanadis
May 3, 2013·Journal of Clinical Periodontology·Francesco D'AiutoJohn C Gunsolley
May 27, 2011·European Journal of Heart Failure·Caterina MammiGiuseppe Massimo Claudio Rosano
Dec 3, 2014·Journal of the American College of Cardiology·Nadia R Sutton, David J Pinsky
Oct 3, 2014·BioMed Research International·Gang WuVeena Dhawan
Oct 30, 2007·Journal of the American College of Cardiology·Erdal CavusogluJonathan D Marmur
Jan 20, 2012·International Journal of Cardiology·Pirkko J PussinenErkki Pesonen

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