Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus

Molecular Reproduction and Development
K J LecoG A Schultz

Abstract

Embryo implantation in the mouse is a highly orchestrated process, a key aspect of which is the invasion of trophoblast cells of the blastocyst into the maternal uterine endometrium. Invasion is facilitated via proteinases expressed by trophoblast cells and balanced by expression of inhibitors of proteinases in the maternal decidua. The predominant proteinase expressed by trophectodermal derivatives of the implanting mouse embryo is matrix metalloproteinase-9 (MMP-9; gelatinase B). Using in situ hybridization, transcripts for MMP-9 were detected in trophoblast cells of the embryo from the earliest stage of decidual formation (day 6.0) examined. MMP-9 transcripts were localized to trophoblast giant cells at the periphery of the embryo at the egg cylinder stage (day 7.0). By the neural-fold stage (day 8.5), expression was restricted to giant cells adjacent to the maternal side of the developing placenta, and by day 9.5 few MMP-9-positive cells remained. The major tissue inhibitor of metalloproteinases (TIMP) produced during this period was TIMP-3. Transcripts encoding TIMP-3 were detected from day 6.0-7.0 in the maternal decidua immediately adjacent to embryonic cells expressing MMP-9. The intensity of TIMP-3 expression in later-...Continue Reading

References

Oct 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C H Graham, P K Lala
Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Matrisian
Aug 1, 1991·Journal of Cellular Physiology·C H Graham, P K Lala
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H BhattC L Stewart
Apr 1, 1991·The Journal of Cell Biology·C L LibrachS J Fisher
Aug 1, 1989·The Journal of Cell Biology·S J FisherC H Damsky
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G I GoldbergC S He
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·W F Bodmer
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J Blenis, S P Hawkes
Apr 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P ReponenK Tryggvason
Mar 1, 1995·Human Reproduction·M B HarveyG A Schultz
Sep 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K S SturmR A Pedersen
Aug 1, 1994·Biology of Reproduction·M Y Arcellana-Panlilio, G A Schultz
Jul 1, 1993·Molecular Reproduction and Development·P WaterhouseR Khokha
Feb 15, 1993·Biochemical and Biophysical Research Communications·H TanakaK Sugita
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler

❮ Previous
Next ❯

Citations

Feb 18, 1999·The EMBO Journal·M Schorpp-KistnerE F Wagner
Aug 29, 2006·Biochemical and Biophysical Research Communications·Claire E QuinnThomas G Kennedy
Mar 28, 2006·Biochemical and Biophysical Research Communications·Guoyi LiuCheng Zhu
May 23, 2001·Biology of Reproduction·H C Keith HoB P Schick
Jun 25, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Jennifer L Herington, Brent M Bany
Jun 8, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Xiaoyan QiuKristina Gemzell-Danielsson
May 9, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K AirolaU K Saarialho-Kere
Mar 14, 2002·Molecular Reproduction and Development·Becky S Y WongDerrick E Rancourt
Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S AfonsoB Babiarz
Jan 1, 1997·Developmental Genetics·K J LecoG A Schultz
Jan 23, 2002·Molecular Reproduction and Development·Suzanne AfonsoBruce Babiarz
Jan 1, 1997·Developmental Genetics·G A Schultz, D R Edwards
Jan 1, 2008·Molecular Reproduction and Development·Navneet SharmaDerrick Rancourt
Nov 7, 2018·Scientific Reports·A G A VianaA A Moura
Aug 2, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shao-Rong DengYun-Xia Wu
Oct 19, 2002·Journal of Reproductive Immunology·Lorraine RobbLois A Salamonsen
Apr 13, 2005·Reproductive Biomedicine Online·Vasilis MinasAntonis Makrigiannakis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.