Tissue kallikrein permits early renal adaptation to potassium load.

Proceedings of the National Academy of Sciences of the United States of America
Soumaya El MoghrabiRégine Chambrey

Abstract

Tissue kallikrein (TK) is a serine protease synthetized in renal tubular cells located upstream from the collecting duct where renal potassium balance is regulated. Because secretion of TK is promoted by K+ intake, we hypothesized that this enzyme might regulate plasma K+ concentration ([K+]). We showed in wild-type mice that renal K+ and TK excretion increase in parallel after a single meal, representing an acute K+ load, whereas aldosterone secretion is not modified. Using aldosterone synthase-deficient mice, we confirmed that the control of TK secretion is aldosterone-independent. Mice with TK gene disruption (TK-/-) were used to assess the impact of the enzyme on plasma [K+]. A single large feeding did not lead to any significant change in plasma [K+] in TK+/+, whereas TK-/- mice became hyperkalemic. We next examined the impact of TK disruption on K+ transport in isolated cortical collecting ducts (CCDs) microperfused in vitro. We found that CCDs isolated from TK-/- mice exhibit net transepithelial K+ absorption because of abnormal activation of the colonic H+,K+-ATPase in the intercalated cells. Finally, in CCDs isolated from TK-/- mice and microperfused in vitro, the addition of TK to the perfusate but not to the peritubu...Continue Reading

References

Jan 1, 1989·Advances in Experimental Medicine and Biology·E MurakamiY Imamura
Jun 1, 1987·Kidney International·C P Vío, C D Figueroa
Jul 1, 1987·Clinical and Experimental Pharmacology & Physiology·A BardenL J Beilin
Jul 1, 1973·The Journal of Physiology·M de Mello-AiresG Malnic
Jun 1, 1966·The American Journal of Physiology·M BurgJ Orloff
Mar 1, 1981·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·G Bönner, M Marin-Grez
Oct 1, 1995·Kidney International·G Giebisch
Mar 21, 1998·The Journal of Clinical Investigation·P MenetonG E Shull
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MenetonF Alhenc-Gelas
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·I ArrighiP Meneton
Feb 24, 2004·Annual Review of Physiology·WenHui Wang
Sep 4, 2004·American Journal of Physiology. Renal Physiology·Pierre MenetonDavid G Warnock
Aug 4, 2005·American Journal of Physiology. Renal Physiology·Régine ChambreyDominique Eladari
Oct 7, 2005·Pflügers Archiv : European journal of physiology·Olivier DherbecourtAlain Doucet
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Nicolas PicardPascal Houillier
Dec 19, 2007·The Journal of Biological Chemistry·Nicolas PicardRégine Chambrey
Jan 8, 2008·Journal of the American Society of Nephrology : JASN·Vladimír PechSusan M Wall
Jul 25, 2008·The Journal of Biological Chemistry·Marcelo D CarattinoThomas R Kleyman
Sep 2, 2008·Annual Review of Physiology·Jang H Youn, Alicia A McDonough
Jul 31, 2009·American Journal of Physiology. Renal Physiology·Michelle L GumzCharles S Wingo
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Daniela Riccardi, Edward M Brown

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Citations

Jun 15, 2011·Current Opinion in Nephrology and Hypertension·Per SvenningsenOle Skøtt
Jun 29, 2011·Current Opinion in Nephrology and Hypertension·Régine Chambrey, Nicolas Picard
Apr 7, 2011·Clinical and Experimental Pharmacology & Physiology·Per SvenningsenBoye L Jensen
May 25, 2012·American Journal of Physiology. Renal Physiology·Ankit B PatelLawrence G Palmer
Aug 13, 2011·Nephron. Physiology·G JacquilletR J Unwin
Apr 11, 2013·Thrombosis and Haemostasis·L WaeckelF Alhenc-Gelas
Sep 21, 2013·The Journal of Clinical Investigation·Victor GueutinRégine Chambrey
Nov 19, 2013·Clinical Proteomics·Mario NavarreteJohn A Wilkins
Sep 6, 2011·Annual Review of Physiology·Dominique EladariJanos Peti-Peterdi
Aug 21, 2013·Seminars in Nephrology·Paul A Welling
Aug 21, 2013·Seminars in Nephrology·Jang H Youn
Oct 24, 2012·Trends in Pharmacological Sciences·Georgia Sotiropoulou, Georgios Pampalakis
Aug 21, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Abdo AsmarCharles S Wingo
Jul 2, 2015·The New England Journal of Medicine·Michelle L GumzCharles S Wingo
Mar 22, 2015·Current Hypertension Reports·Régine Chambrey, Francesco Trepiccione
Jan 7, 2015·Pflügers Archiv : European journal of physiology·David PentonJohannes Loffing
Mar 17, 2016·World Journal of Biological Chemistry·Luciana MorlaGilles Crambert
Jan 3, 2019·Soft Matter·Fernando Peruani, Gustavo J Sibona
Dec 27, 2018·Current Opinion in Nephrology and Hypertension·Stephanie M Mutchler, Thomas R Kleyman
Feb 24, 2015·Nature Reviews. Drug Discovery·Ioannis PrassasEleftherios P Diamandis
Jan 17, 2014·American Journal of Physiology. Renal Physiology·Gilles Crambert
Nov 14, 2019·American Journal of Physiology. Cell Physiology·Thomas R Kleyman, Douglas C Eaton
Mar 31, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amel SalhiGilles Crambert
Jul 7, 2020·American Journal of Physiology. Renal Physiology·Lei YangLawrence G Palmer
Jan 9, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco TrepiccioneDominique Eladari
Nov 10, 2017·Annual Review of Physiology·Thomas R KleymanRebecca P Hughey
Mar 4, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Lucas Barberis, Ezequiel V Albano
Feb 19, 2021·Soft Matter·Oleksandr ChepizhkoFernando Peruani
Jun 7, 2013·Physical Review Letters·Oleksandr ChepizhkoFernando Peruani
Apr 4, 2021·Pharmaceuticals·Jean-Pierre GirolamiFrancois Alhenc-Gelas
Feb 9, 2021·American Journal of Physiology. Renal Physiology·Niklas AyasseJens Leipziger
Sep 8, 2018·Journal of Proteome Research·Mario NavarreteJohn A Wilkins

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