Tissue metabolism and the inflammatory bowel diseases

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Jordi M LanisSean P Colgan

Abstract

The intestinal mucosa provides a selective barrier between the anaerobic lumen and a highly metabolic lamina propria. A number of recent studies indicate that acute inflammation of the mucosa can result in tissue hypoxia and associated shifts in tissue metabolism. The activation of hypoxia-inducible factor (HIF) under these conditions has been demonstrated to function as an endogenous molecular cue to promote resolution of inflammation, particularly through the orchestration of barrier repair toward homeostasis. Given the central role of oxygen in tissue metabolism, ongoing studies have defined metabolic endpoints of HIF stabilization as important biomarkers of disease activity. Such findings make HIF and HIF-associated metabolic pathways particularly attractive therapeutic targets in inflammatory bowel disease (IBD). Here, we review the recent literature related to tissue metabolism in IBD.

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Citations

Aug 7, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Viola NeudeckerHolger K Eltzschig
Mar 23, 2018·Critical Reviews in Food Science and Nutrition·Fernando Cunha NetoSandra Maria Barbalho
Feb 26, 2019·Frontiers in Pharmacology·Francesco CappelloAlberto J L Macario
Feb 23, 2018·World Journal of Gastroenterology : WJG·Flavia MerigoGiacomo Carlo Sturniolo
Feb 26, 2021·Metabolism: Clinical and Experimental·Christopher AugerMarc G Jeschke
Jun 1, 2021·Frontiers in Pharmacology·Helene Kolstad SkovdahlTorunn Bruland
Jul 5, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ankit VermaVarda Shoshan-Barmatz

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