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Tissue metabolites of trifluorperazine, fluphenazine, prochlorperazine, and perphenazine. Kinetics in chronic treatment

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

H J GaertnerU Breyer

PMID: 1218

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Abstract

Repeated oral treatment of male rats with piperazine-substituted phenothiazine drugs in doses of 25 mg/kg or more daily led to an accumulation of metabolites containing an ethylenediamine group instead of the piperazine ring. These products of ring degradation with and without removal o...read more

Mentioned in this Paper

Compazine
Canis familiaris
Lyogen
Trilafon
Dealkylation
Triftazin
Kidney
Malonates
Liver
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  • Tissue metabolites of trifluorperazine, fluphenazine, prochlorperazine, and perphenazine. Kinetics in chronic treatment

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    H J GaertnerU Breyer

    PMID: 1218

    DOI:

    Abstract

    Repeated oral treatment of male rats with piperazine-substituted phenothiazine drugs in doses of 25 mg/kg or more daily led to an accumulation of metabolites containing an ethylenediamine group instead of the piperazine ring. These products of ring degradation with and without removal o...read more

    Mentioned in this Paper

    Compazine
    Canis familiaris
    Lyogen
    Trilafon
    Dealkylation

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