Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors

Archives of Dermatology
Peter J WildAnja Katrin Bosserhoff

Abstract

Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTAP) protein expression is associated with clinicopathologic variables in benign and malignant melanocytic skin tumors. Cytoplasmic MTAP expression was detected in 227 (72.1%) of 315 informative cases. Expression was significantly reduced in primary malignant melanomas and in melanoma metastases compared with benign nevi (P<.001 for both). No difference was noted in MTAP expression between primary malignant melanomas and melanoma metastases. In primary malignant melanomas, a Ki67-labeling index less than 5% was associated with MTAP expression (P = .04), suggesting that loss of MTAP expression is associated with proliferation. No other variables had significant associations with MTAP expression. Lymph node metastases demonstrated significantly higher MTAP expression compared with skin metastases (P = .01). In the overall cohort, MTAP expression was not associated with prognosis. Among 26 patients with MTAP-positive melanomas and tumor recurrence, 18 patients who received interferon therapy had a significant benefit compared with 8 patients who did not receive interferon therapy (P = .009). This was not seen in the patients with MTAP-negative tu...Continue Reading

Citations

Sep 25, 2012·The American Journal of Dermatopathology·Thilo GambichlerFalk G Bechara
Mar 21, 2007·Pigment Cell Research·Alexandra E DenkAnja K Bosserhoff
Mar 21, 2007·Pigment Cell Research·Tanja Rothhammer, Anja-Katrin Bosserhoff
Jun 1, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Peter J WildAnja Katrin Bosserhoff
Feb 14, 2016·The Journal of Investigative Dermatology·Wesley J WoollardTracey J Mitchell
Aug 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Katharina LimmAnja-Katrin Bosserhoff

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