PMID: 15220792Jun 29, 2004Paper

Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception

Anesthesiology
Alexander BrackC Stein

Abstract

Opioid-containing leukocytes migrate to peripheral sites of inflammation. On exposure to stress, opioid peptides are released, bind to opioid receptors on peripheral sensory neurons, and induce endogenous antinociception. In later stages of Freund's complete adjuvant-induced local inflammation, monocytes/macrophages are a major opioid-containing leukocyte subpopulation, but these cells also produce proalgesic cytokines. In this study, the role of tissue monocytes/macrophages in hyperalgesia and in peripheral opioid-mediated antinociception was investigated. After intraplantar injection of Freund's adjuvant, leukocyte subpopulations and opioid-containing leukocytes were analyzed by flow cytometry in the inflamed paw in the presence or absence of monocyte/macrophage depletion by intraplantar injection of clodronate-containing liposomes (phosphate-buffered saline and empty liposomes served as controls). Paw volume was measured with a plethysmometer. Hyperalgesia was determined by measuring heat-induced paw withdrawal latency and paw pressure threshold. Paw pressure threshold was also measured after swim stress and injection of fentanyl. At 48 and 96 h of inflammation, it was found that (1). monocytes/macrophages were the largest l...Continue Reading

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Citations

Jan 15, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Halina Machelska
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Halina Machelska, Christoph Stein
Apr 10, 2008·British Journal of Anaesthesia·H L RittnerC Stein
Jul 21, 2005·Mediators of Inflammation·Magdalena ChadzinskaBarbara Plytycz
Jul 13, 2014·European Journal of Pharmacology·Mariana Silva QuinteiroJuliana Trindade Clemente-Napimoga
Jan 8, 2008·Current Rheumatology Reports·Heike L Rittner, Alexander Brack
May 6, 2014·The Journal of Pain : Official Journal of the American Pain Society·Hanneke L D M WillemenAnnemieke Kavelaars
May 21, 2013·The Journal of Pain : Official Journal of the American Pain Society·Diana PflückeHeike L Rittner
Nov 3, 2009·Brain, Behavior, and Immunity·Melanie Busch-Dienstfertig, Christoph Stein
Jan 20, 2009·Brain Research Reviews·Christoph SteinRobert H Spencer
May 20, 2008·Journal of Neuroimmunology·Alan BénardGilles Dietrich
Apr 2, 2008·Neuroscience Letters·H L RittnerC Stein
Jul 21, 2007·Neuropeptides·Halina Machelska
Mar 2, 2005·European Journal of Pain : EJP·H L Rittner, C Stein
Jun 3, 2008·The European Journal of Neuroscience·Claire Gavériaux-RuffBrigitte L Kieffer
Jun 20, 2006·Explore : the Journal of Science and Healing·Grant G ZhangBrian M Berman
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Apr 26, 2015·Brain Research·Jill-Desiree Brederson, Christopher N Honda
Jun 4, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C G MacedoJ T Clemente-Napimoga
Oct 9, 2016·Journal of Neuroinflammation·Maria PannellHalina Machelska
Mar 9, 2006·Journal of Leukocyte Biology·Heike L RittnerAlexander Brack
Dec 13, 2005·Journal of Neurophysiology·Heather N WenkChristopher N Honda
Oct 25, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heike L RittnerAlexander Brack
Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Feb 28, 2020·JCI Insight·Melih Ö CelikHalina Machelska
Oct 12, 2007·The Journal of Pharmacology and Experimental Therapeutics·Marcelo H NapimogaSérgio H Ferreira
Oct 5, 2011·Pharmacological Reviews·Christoph Stein, Halina Machelska
May 22, 2021·Frontiers in Neuroscience·Qing LiuFang Huang
Jul 17, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Valentina MalafogliaAntonello Bonci

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