Tissue-of-origin-specific gene repositioning in breast and prostate cancer

Histochemistry and Cell Biology
Karen J MeaburnTom Misteli

Abstract

Genes have preferential non-random spatial positions within the cell nucleus. The nuclear position of a subset of genes differ between cell types and some genes undergo repositioning events in disease, including cancer. It is currently unclear whether the propensity of a gene to reposition reflects an intrinsic property of the locus or the tissue. Using quantitative FISH analysis of a set of genes which reposition in cancer, we test here the tissue specificity of gene repositioning in normal and malignant breast or prostate tissues. We find tissue-specific organization of the genome in normal breast and prostate with 40 % of genes occupying differential positions between the two tissue types. While we demonstrate limited overlap between gene sets that repositioned in breast and prostate cancer, we identify two genes that undergo disease-related gene repositioning in both cancer types. Our findings indicate that gene repositioning in cancer is tissue-of-origin specific.

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Citations

Feb 20, 2016·Histochemistry and Cell Biology·Klara Weipoltshammer, Christian Schöfer
Aug 10, 2018·PLoS Neglected Tropical Diseases·Joanna M BridgerMatty Knight
Mar 5, 2019·Genes, Chromosomes & Cancer·Teresa SzczepińskaDariusz Plewczynski
Jan 29, 2020·Journal of Cell Science·Roopali PradhanKundan Sengupta
Jan 3, 2018·Systems Biology in Reproductive Medicine·Dimitrios Ioannou, Helen G Tempest
Apr 24, 2018·Nucleic Acids Research·Roopali PradhanKundan Sengupta
Sep 22, 2018·Histochemistry and Cell Biology·Carmen AdriaensTom Misteli
Feb 10, 2017·Methods : a Companion to Methods in Enzymology·Elizabeth H FinnTom Misteli
Apr 30, 2021·Frontiers in Molecular Biosciences·Chengwei Zhang, Jing Huang

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