Tissue Patterning: Translating Design Principles from In Vivo to In Vitro

Annual Review of Biomedical Engineering
Alison P McGuigan, Sahar Javaherian

Abstract

Recapitulating the architecture of native tissue remains a significant challenge, impeding the progress of engineering tissues. Imposing appropriate organization is especially challenging in tissues that contain multiple cellular components in complex structural units. One solution is to mimic developmental processes in embryos. In an embryo, cells are organized by tissue patterning, whereby induction of fate-determining genes is spatially controlled to generate patterns of cell differentiation and maturation. Following patterning, the imposed cell organization is further reinforced by implementation of compartment boundaries, which prevent intermingling of cells from distinct phenotypic domains, thereby ensuring preservation of proper cell organization in growing and reorganizing tissues. Both morphogenic processes utilize a conserved set of fundamental principles, the implementation of which leads to highly regulated cell organization. In this article, we review these patterning principles in vivo and reflect on the progress made by tissue engineers in mimicking tissue patterning ex vivo.

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Gossen, H Bujard
Jul 1, 1988·Cell·W Driever, C Nüsslein-Volhard
Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M S Steinberg, M Takeichi
Feb 11, 1994·Cell·J Heemskerk, S DiNardo
Sep 1, 1996·Nature Medicine·V M RiveraM Gilman
Feb 1, 1997·Journal of Biomedical Materials Research·S N BhatiaM Toner
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·D T ChiuG M Whitesides
Oct 19, 2000·Journal of Biomechanical Engineering·G W Brodland, H H Chen
Jan 4, 2001·Cell·E V EntchevM González-Gaitán
Feb 17, 2001·Current Opinion in Neurobiology·J Briscoe, J Ericson
Apr 3, 2001·Trends in Cardiovascular Medicine·R H Adams, R Klein
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·M N YousafM Mrksich
Jul 4, 2001·The EMBO Journal·M AffolterA Jaźwińska
Oct 5, 2001·Nature Reviews. Genetics·M Lewandoski
Oct 26, 2001·Nature·J B Gurdon, P Y Bourillot
Nov 1, 2001·Annual Review of Cell and Developmental Biology·K D Irvine, C Rauskolb
Feb 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joe TienChristopher S Chen
May 25, 2002·Developmental Biology·Angelike Stathopoulos, Michael Levine
Aug 30, 2002·Current Opinion in Genetics & Development·Ulrich TepassRudolf Winklbauer
Sep 11, 2002·Developmental Biology·Andrea Streit
Dec 25, 2002·Chemistry & Biology·Weiying LinDavid S Lawrence
Feb 8, 2003·The EMBO Journal·Masamitsu TanakaHaruhiko Sugimura

❮ Previous
Next ❯

Citations

Oct 28, 2016·Advanced Materials·Xiao HuangNorbert O Reich
Jun 14, 2021·Journal of Theoretical Biology·Xiaoliang Wang, Andrew Harrison
Sep 26, 2021·Advanced Materials·Sang Ah YiKi-Bum Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
Confocal microscopy
bioprinting

Software Mentioned

DITH

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annual Review of Biochemistry
Yosef Gruenbaum
Annual Review of Biomedical Engineering
Majid Ebrahimi WarkianiJongyoon Han
Annual Review of Cell and Developmental Biology
Alex J BlaskyRytis Prekeris
Annual Review of Pharmacology and Toxicology
Rong Tong, Daniel S Kohane
© 2022 Meta ULC. All rights reserved