Tissue penetration and pharmacokinetics of lomefloxacin following multiple doses

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J KaviR Wise

Abstract

The pharmacokinetics of lomefloxacin were studied after three days of oral administration of 400 mg/day lomefloxacin. Following the final dose the concentrations in serum, urine and cantharidin-induced inflammatory fluid were measured by a microbiological assay. The mean peak serum level was 4.9 mg/l at a mean time of 0.8 h. The mean serum elimination half-life was 6.2 h. The mean maximum inflammatory fluid level attained was 3.2 mg/l at 2.7 h. Urinary recovery accounted for the greater part of lomefloxacin's elimination.

References

Feb 1, 1987·Antimicrobial Agents and Chemotherapy·R WiseD J Griggs
Oct 1, 1988·Antimicrobial Agents and Chemotherapy·J W StoneR Wise
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·R WiseJ M Andrews
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·T HiroseS Mitsuhashi
Jan 1, 1984·The Journal of Antimicrobial Chemotherapy·Z N AdhamiB Crump
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·B CrumpJ Dent
Jul 1, 1980·The Journal of Infectious Diseases·R WiseS Baker

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Citations

Aug 1, 1996·Nuclear Medicine and Biology·T J TewsonP Frank
Dec 1, 1992·The American Review of Respiratory Disease·C PiersimoniG Scalise
Apr 6, 1992·The American Journal of Medicine·T G Mant
May 20, 2020·Applied Microbiology and Biotechnology·Tamara I ZemskayaFrancisco Rodriguez-Valera

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