PMID: 9181388May 1, 1997Paper

Tissue penetration of sparfloxacin in a rat model of experimental Escherichia coli epididymitis

Infection
M LudwigW Weidner

Abstract

The epididymal, testicular, and prostatic tissue penetration of sparfloxacin, a new quinolone, was assessed in a rat model of acute epididymitis. Seventy-two hours after injection of 0.1 ml (10(6) cfu/ml) of an Escherichia coli suspension into the right epididymis via the right ductus deferens, a single oral dose of sparfloxacin 50 mg/kg body weight was administered. One, 2, 4, 8, 12, and 24 h after administration the animals were sacrificed and the sparfloxacin concentrations and "areas under the curve" (AUC0-24) in both epididymides, both testes, the prostate gland and in the serum were measured by bioassay. The highest mean AUC0-24 was found in the prostate gland, followed by left epididymis, right epididymis, serum, right testis, and left testis (190, 79, 60, 28, 12, and 9 mg/kg x h, respectively). Though there was no statistically significant difference in the sparfloxacin concentration of both epididymides (p = 0.09), the mean AUC0-24 was significantly higher in the non-infected left epididymis (p < 0.0001). The AUC0-24 and sparfloxacin concentrations of the right infected epididymis were significantly higher than those observed in the serum (p < 0.0001). In both testes, the AUC0-24 and sparfloxacin concentrations were lo...Continue Reading

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Citations

Apr 2, 2016·Der Urologe. Ausg. A·A Kaminsky, H Sperling
May 25, 2016·The Journal of Pathology·Vera MichelAndreas Meinhardt
Nov 30, 2014·International Journal of Toxicology·Tamiko AdachiNaoya Masutomi
Oct 19, 2017·Der Internist·J MarconG Magistro
Feb 17, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Laura RyanMaeve Doyle
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sudhanshu BhushanAndreas Meinhardt

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