Tissue plasminogen activator-based clot busting: Controlled delivery approaches

Global Cardiology Science & Practice
Ibrahim M El-SherbinyMagdi H Yacoub

Abstract

Cardiovascular diseases are the leading cause of death worldwide. Thrombosis, the formation of blood clot (thrombus) in the circulatory system obstructing the blood flow, is one of the main causes behind various ischemic arterial syndromes such as ischemic stroke and myocardial infarction, as well as vein syndromes such as deep vein thrombosis, and consequently, pulmonary emboli. Several thrombolytic agents have been developed for treating thrombosis, the most common being tissue plasminogen activator (tPA), administrated systemically or locally via IV infusion directly proximal to the thrombus, with the aim of restoring and improving the blood flow. TPA triggers the dissolution of thrombi by inducing the conversion of plasminogen to protease plasmin followed by fibrin digestion that eventually leads to clot lysis. Although tPA provides powerful thrombolytic activity, it has many shortcomings, including poor pharmacokinetic profiles, impairment of the reestablishment of normal coronary flow, and impairment of hemostasis, leading to life-threatening bleeding consequences. The bleeding consequence is ascribed to the ability of tPA to circulate throughout the body and therefore can lysis all blood clots in the circulation system, ...Continue Reading

References

Sep 1, 1978·British Journal of Haematology·A R WilliamsJ H Sanderson
Oct 1, 1991·Circulation·M ArianiR J Siegel
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M S RungeE Haber
Jan 1, 1995·Ultrasound in Medicine & Biology·C W FrancisC Cox
Dec 15, 1994·The American Journal of Cardiology·U RosenscheinH I Miller
Jan 1, 1994·IEEE Transactions on Bio-medical Engineering·M A Moehring, J R Klepper
Nov 22, 1996·Biochimica Et Biophysica Acta·A N Nikolova, M N Jones
Dec 24, 1997·Progress in Cardiovascular Diseases·A E Schussheim, V Fuster
May 18, 1999·International Journal of Cardiology·P R Eisenberg, G Ghigliotti
Oct 29, 2000·Ultrasound in Medicine & Biology·E C Everbach, C W Francis
Apr 27, 2001·Echocardiography·C W Francis
Sep 6, 2001·Stroke; a Journal of Cerebral Circulation·C A MolinaJ Alvarez-Sabín
Jan 5, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·T R PorterF Xie
Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·J F LiangV C Yang
Jan 10, 2002·Journal of Neurotrauma·P L GrundyP M Sharples
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
Apr 8, 2003·Current Medicinal Chemistry·M C Pedroso de LimaS Simões
Jun 5, 2003·Annals of Neurology·Jürgen EggersGünter Seidel
Apr 28, 2004·Advanced Drug Delivery Reviews·Evan C UngerReena Zutshi
Jun 29, 2004·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·P A DijkmansO Kamp
Oct 9, 2004·Biochimica Et Biophysica Acta·Shao-Ling Huang, Robert C MacDonald
Nov 19, 2004·The New England Journal of Medicine·Andrei V AlexandrovUNKNOWN CLOTBUST Investigators
Jun 25, 2005·Journal of Thrombosis and Thrombolysis·Alain ViguierVincent Larrue
Jul 13, 2005·Journal of Colloid and Interface Science·Chia-Lung LinWen-Yen Chiu
Nov 2, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Victor C YangJun F Liang
Nov 9, 2005·Vascular Pharmacology·Dev B BaruahS S Kadam
Aug 5, 2006·Thrombosis Research·Susan D Tiukinhoy-LaingDavid D McPherson
Apr 7, 2007·Ultrasound in Medicine & Biology·Denise A B SmithChristy K Holland
Apr 7, 2007·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·S Dean Allison

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Citations

Sep 19, 2019·Journal of Thrombosis and Haemostasis : JTH·Dante DisharoonKeith B Neeves
Mar 27, 2020·International Journal of Nanomedicine·Sebastian P PernalHerbert H Engelhard
Jan 20, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Ali AmaniMohamadamin Forouzandehmehr

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BETA
ELIP

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CLOTBUST

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