PMID: 2495913May 1, 1989Paper

Tissue plasminogen activator in acute pulmonary embolism

Chest
S Z Goldhaber

Abstract

The use of thrombolytic therapy to treat AMI has reawakened interest in thrombolysis for acute pulmonary embolism (PE). We have investigated the use of recombinant human tissue-type plasminogen activator (rtPA) in patients with acute PE. In an open label study, rtPA achieved more than 90% efficacy and safety. In a trial comparing rtPA with an FDA-approved dose of urokinase (UK), rtPA appeared more rapid and safer. We are now conducting a comparative trial of rtPA with a novel dosing regimen of UK. In addition, a concurrent trial is comparing rtPA vs heparin for improvement in right ventricular function, assessed by echocardiography, among PE patients. However, the greatest challenge in PE research is to undertake a large-scale trial that compares thrombolysis and heparin for reduction of clinically relevant end points such as mortality and recurrent PE.

References

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Citations

Feb 21, 2002·International Journal of Cardiology·L B YapJ C Forfar
Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C McSharryG Boyd
Jul 2, 2014·AIDS·Shoba Reddy-HoldcraftAnurag K Agrawal
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Mar 12, 2005·Southern Medical Journal·Nancy M TofilMargaret K Winkler
Dec 18, 2009·Southern Medical Journal·Muthiah P Muthiah, Muhammad K Zaman
May 2, 2014·The American Journal of Forensic Medicine and Pathology·Ritesh G MenezesSavita Lasrado
Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Agnieszka Kokoszka, Noah Scheinfeld
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Nov 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·R J MaillouxD F Kirby

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