Tissue plasminogen activator in chronic subdural hematomas as a predictor of recurrence

Journal of Neurosurgery
Hiroyuki KatanoKazuo Yamada

Abstract

Chronic subdural hematomas (CSDHs) recur in 7 to 18% of cases. The present study was conducted to determine whether serum or lesion concentrations of coagulofibrinolytic and angiogenic factors, which have been reported to be potential markers of CSDH development, might predict such recurrences. Sixty consecutive patients (mean age 71.5 years) with CSDHs (74 affected sides) were studied. Samples of serum in preoperative peripheral venous blood and of hematomas (obtained during surgery) were collected and analyzed. The CSDH recurred in six (8.1%) of the 74 affected sides in six patients. None of the values of the coagulative factors or tests in serum showed significant variation between cases with and those without recurrence. Among coagulofibrinolytic factors, tissue plasminogen activator (TPA) in hematomas demonstrated significantly greater levels in recurrent than in nonrecurrent cases; a similar tendency was noted for alpha2-plasmin inhibitor-plasmin complex in hematomas. Both factors were greater in the lesions than in the serum. Among the angiogenic factors, levels of hepatic growth factor (HGF) and vascular endothelial growth factor (VEGF) in hematomas were significantly greater than in serum, whereas those of basic fibrob...Continue Reading

References

Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TsubouchiS Kawakami
Jul 1, 1989·Neurosurgery·Y KawakamiY Shimamura
Sep 1, 1988·Surgical Neurology·H ItoT Hasegawa
Aug 16, 1984·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Jan 8, 1999·International Journal of Cardiology·A KawamotoK Dohi
Sep 6, 2001·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·T ShonoM Fukui
Sep 20, 2001·Neurologia Medico-chirurgica·M OishiM Saito
Feb 13, 2003·Acta Neurologica Scandinavica·S A KönigH-E Vitzthum

❮ Previous
Next ❯

Citations

Apr 25, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Milo StanisicTerje Sæhle
Aug 7, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Gurpreet S GandhokePeter Nakaji
Feb 12, 2011·Journal of Neurotrauma·Mikiko FunaiMasakazu Takayasu
Jul 6, 2014·Journal of Neurosurgery·Weiming LiuRob J M Groen
Apr 24, 2009·Acta neurochirurgica·A AkhaddarM Boucetta
Nov 29, 2011·World Neurosurgery·Hannah GoldsteinE Sander Connolly
Dec 7, 2013·Neurologia Medico-chirurgica·Atsushi SaitoMichiharu Nishijima
Apr 30, 2014·Journal of the Neurological Sciences·Tuo LiJianning Zhang
Oct 4, 2016·Asian Journal of Neurosurgery·Yad R YadavJitin Bajaj
Sep 11, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Kazuya MatsuoTatsuya Nagashima
Jul 1, 2017·Journal of Neurotrauma·Koji OsukaMasakazu Takayasu
Oct 5, 2017·Clinical Neuropharmacology·Mark B FrenkelDaniel E Couture
Jun 1, 2017·Journal of Neuroinflammation·Ellie EdlmannPeter J Hutchinson

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.