PMID: 2107957Feb 1, 1990Paper

Tissue plasminogen activator in peripheral arterial thrombolysis

The British Journal of Surgery
D C BerridgeB R Hopkinson

Abstract

Thirty acute peripheral arterial thromboses in 28 patients were treated with local low-dose intra-arterial recombinant tissue plasminogen activator (t-PA). All patients received 0.5 mg h-1 t-PA and 15 also received 250 units h-1 of intra-arterial heparin. Overall limb salvage at 30 days was 83 per cent (25 out of 30 limbs). Mean(s.d.) ankle/brachial index was increased by 0.53(0.26) and there was no significant difference between the group receiving t-PA alone and that receiving t-PA and heparin. No strokes or major haemorrhages occurred but there were four (13 per cent) minor haematomas associated with the catheter entry site. There were four (13 per cent) deaths from myocardial infarction occurring between 5 and 21 days after treatment. Rethrombosis occurred in four cases (13 per cent). In two patients following t-PA alone, rethrombosis occurred after 2 and 11 days. Limb salvage was achieved with a successful repeat thrombolysis and a femoropopliteal graft respectively. Rethrombosis after t-PA and heparin occurred after 30 days in two patients due to poor run-off and extensive proximal atheromatous disease respectively. t-PA is a safe, effective thrombolytic agent when given as a low-dose intra-arterial infusion. The addition...Continue Reading

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Citations

May 1, 1992·Clinical Radiology·J McCallG Hamilton
Dec 1, 1990·Clinical Radiology·K DawsonG Hamilton
Oct 3, 2002·Thrombosis Research·Vincenzo Costantini, Massimo Lenti
Aug 1, 1991·European Journal of Vascular Surgery·D J BrowseR B Galland
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Dec 5, 2003·Journal of Vascular and Interventional Radiology : JVIR·Mahmood K RazaviLawrence V Hofmann
Jan 8, 2004·Journal of Vascular and Interventional Radiology : JVIR·Mahmood K RazaviLawrence V Hofmann
Dec 23, 2011·Annals of Vascular Surgery·Christian Ochoa, Fred A Weaver
Nov 1, 1995·Journal of Vascular and Interventional Radiology : JVIR·M F Meyerovitz
Jan 15, 2002·Journal of Vascular and Interventional Radiology : JVIR·Peter DrescherWilliam S Rilling
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