PMID: 2497501Jan 1, 1989Paper

Tissue plasminogen activator in the treatment of experimental retinal vein occlusion

Retina
M OncelB Khoobehi

Abstract

The thrombolytic effect of recombinant tissue plasminogen activator was studied in 28 randomly selected rabbit eyes to lyse photochemically induced retinal vein occlusion. Occlusion was confirmed histologically and assessed by fluorescein angiography. Sixteen eyes were treated with recombinant tissue plasminogen activator given intravenously and 12 control eyes were given similar volumes of normal saline solution. Fluorescein angiography was performed before and at various intervals after treatment. Four hours after treatment, the retinal vein was patent in 16 eyes (100%) treated with recombinant tissue plasminogen activator, as opposed to one eye (8.3%) treated with normal saline. The results indicate that tissue plasminogen activator is effective in lysing experimentally induced retinal vein thrombi.

Citations

Apr 1, 1993·International Ophthalmology·C KoutsandreaP Theodossiadis
Jul 22, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hossein AmeriMark S Humayun
Jan 6, 2004·International Ophthalmology Clinics·Atul Sharma, Donald J D'Amico
Feb 1, 1994·Australian and New Zealand Journal of Ophthalmology·L M Manning, D K Conrad
Oct 1, 1992·The British Journal of Ophthalmology·I L McAllisterI Constable
Feb 4, 1999·The British Journal of Ophthalmology·J LarssonS B Olsson
Mar 9, 2011·Clinical Ophthalmology·Nancy KunjukunjuWilliam S Rodden
Feb 15, 1991·American Journal of Ophthalmology·H LewisB R Straatsma
May 1, 1993·Survey of Ophthalmology·A C Fong, H Schatz
Jan 1, 1992·Acta Ophthalmologica. Supplement·T TervoA Tarkkanen
Jul 31, 2019·Journal of Lasers in Medical Sciences·Salwa Ahmed AbdelkawiAhmed Tamer Sayed Saif

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