Abstract
Depression of fibrinolysis may be relevant to the vascular complications of diabetes mellitus. Plasminogen activator inhibitor (PAI) is an important inhibitor of fibrinolysis in humans, and we have found basal activities of PA inhibition to be elevated in patients with diabetes compared with a reference group of healthy subjects (mean +/- SD 268 +/- 268 vs. 105 +/- 48%; P less than .0001). With a monoclonal antibody, it was shown that high inhibition values were due to PAI-1. No differences in PA inhibition were noted in relation to type of diabetes, diabetic treatment, or presence or absence of vascular complications. Basal PA inhibition did not correlate with in vivo (B beta 15-42 antigen) or ex vivo (fibrin plate) fibrinolytic activity or HbA1. In patients with non-insulin-dependent diabetes mellitus, treatment with the anabolic steroid stanozolol significantly reduced PA inhibition. These findings suggest a further abnormality of fibrinolysis in diabetes, but the lack of a relationship among other measures of fibrinolysis renders its biologic significance uncertain.
Citations
Apr 12, 2003·Ophthalmology·Robert HaimoviciJames Melby
Dec 21, 2004·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Cihangir EremMünir Telatar
Jan 1, 1993·International Journal of Clinical & Laboratory Research·S H DondersJ W van Wersch
May 18, 1999·Microvascular Research·S YamagishiH Yamamoto
Sep 3, 2010·Platelets·M FeuringA Schultz
Sep 24, 2010·Pediatric Diabetes·Matthew P KrauseThomas J Hawke
Aug 1, 1995·Journal of the American Academy of Dermatology·T Helfman, V Falanga
Sep 15, 1992·Thrombosis Research·F CarmassiG Mariani
Aug 1, 1993·Metabolism: Clinical and Experimental·B J Potter van LoonA E Meinders
Oct 1, 1993·International Journal of Cardiology·H OgawaH Yasue
Aug 1, 1992·American Heart Journal·T MasudaH Kato
Mar 5, 1998·Journal of the American Academy of Dermatology·D Parsad, R Saini
May 20, 2011·Diabetes·Matthew P KrauseThomas J Hawke
Nov 25, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Christopher P GaleLucinda K M Summers
Feb 6, 2015·The International Journal of Lower Extremity Wounds·Polly CarsonVincent Falanga
Sep 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Banu Pinar Sarer YürekliAlper Gürlek
Sep 23, 1997·Biochemical and Biophysical Research Communications·D I HolmesR M Mason
May 1, 1992·Metabolism: Clinical and Experimental·J Gram, J Jespersen