Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation

Neuroreport
D CentonzeP Calabresi

Abstract

Recent experimental observations indicate that tPA plays a key role in the development of neuronal damage that follows cerebral ischemia and excitotoxicity. In an attempt to clarify how tPA favors ischemia-induced neuronal damage, we performed in vitro electrophysiological experiments in striatal slices by using mice selectively lacking this serine protease.We found that tPA ablation did not affect the membrane depolarization of striatal neurons exposed to combined oxygen and glucose deprivation but fully prevented the induction of NMDA-dependent post-ischemic long-term synaptic potentiation. The absence of striatal post-ischemic pote ntiat ion observed in tPA-lacking mice may account for the significant neuroprotection observed in these animals after the occlusion of middle cerebral artery.

References

Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B Nellgård, T Wieloch
Jul 1, 1989·The Journal of Cell Biology·S Verrall, N W Seeds
Oct 1, 1988·Journal of Neuroscience Research·S Verrall, N W Seeds
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E F PlowJ L Hoover-Plow
Feb 14, 1998·Nature Medicine·G J del Zoppo
Sep 11, 1999·Trends in Neurosciences·M Roy, R Sapolsky
Apr 13, 2000·The European Journal of Neuroscience·P CalabresiA Gulino
Jun 15, 2000·Journal of Molecular Neuroscience : MN·E KohmuraT Yoshimine
Aug 15, 2000·Trends in Neurosciences·M B Gingrich, S F Traynelis

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Citations

Sep 25, 2003·Lancet Neurology·Paolo CalabresiGiorgio Bernardi
Nov 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tomasz MatysSidney Strickland
Aug 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Erin H Norris, Sidney Strickland
Nov 4, 2015·Frontiers in Cellular Neuroscience·Arnaud ChevilleyDenis Vivien
May 15, 2004·Progress in Neurobiology·John W Wright, Joseph W Harding

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