Tissue protein synthesis rates in critically ill patients

Critical Care Medicine
Pia EssénJan Wernerman

Abstract

The aims of this study were to simultaneously determine the in vivo rates of protein synthesis in skeletal muscle, peripheral blood lymphocytes, and serum albumin in critically ill patients; to establish whether a relationship between the responses of these tissues could be observed; and to demonstrate if a protein synthesis pattern characteristic of critical illness exists. Descriptive study. Intensive care unit of a 1000-bed university hospital. Fifteen patients treated in the intensive care unit. None. Rates of tissue protein synthesis were determined in vivo once during the course of critical illness, using the flooding method with L-(2H5)phenylalanine. Protein synthesis in muscle was 1.49 +/- 0.16%/day; in circulating lymphocytes (i.e., mononuclear cells), protein synthesis was 11.10 +/- 1.82%/day. Albumin synthesis was 12.81 +/- 1.23%/day when expressed as the fractional rate, and was 184 +/- 19 mg/kg/day when expressed as the absolute rate. The individual tissues responded differently to trauma, and showed a wide range of values. The responses were not significantly correlated with each other and no pattern of tissue protein synthesis characteristic of critical illness was observed. However, both muscle protein and album...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Immunology·N Skaug, T Hofstad
Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Apr 1, 1991·Acta Anaesthesiologica Scandinavica·G Akerström, B Lisander
Jun 1, 1987·The Journal of Clinical Investigation·H J MoshageS H Yap
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·W W SoubaD W Wilmore
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
May 1, 1973·Circulation Research·H P Parving, F Gyntelberg
Aug 26, 1983·Journal of Chromatography·T TomonoE Tokunaga
Mar 1, 1984·Metabolism: Clinical and Experimental·M J RennieK Lundholm
Feb 1, 1983·Archives of Surgery·S RosenblattB Lindberg
Aug 1, 1983·Clinical Science·M B ClagueI D Johnston
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P E BallmerP J Garlick
Mar 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·I TjäderM A McNurlan
Jul 1, 1996·Clinical Science·P EssénP J Garlick
Nov 1, 1996·Metabolism: Clinical and Experimental·M A McNurlanJ Wernerman
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·L ERIKSEN

❮ Previous
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Citations

May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·P J Garlick, E Cersosimo
Nov 13, 2004·The Journal of Nutritional Biochemistry·F SternY Dror
Dec 17, 2002·Current Opinion in Pharmacology·Julia S Hadley, Charles J Hinds
Oct 8, 2005·Postgraduate Medical Journal·R D Griffiths, T Bongers
Jul 1, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Thomas GamsjägerChristian Weinstabl
Jul 18, 2014·Critical Care : the Official Journal of the Critical Care Forum·Olav Rooyackers, Jan Wernerman
Jan 5, 2010·Wiener klinische Wochenschrift·Bettina LeberVanessa Stadlbauer
Feb 1, 2010·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Bellal JosephRifat Latifi
Dec 26, 2012·The Journal of Physiology·Guillaume RenaudLars Larsson
Jun 15, 2011·The Journal of Physiology·Despina ConstantinPaul L Greenhaff
Oct 22, 2010·The Journal of Physiology·Zudin PuthuchearyNicholas Hart
Jan 8, 2015·Critical Care : the Official Journal of the Critical Care Forum·Peter J M WeijsRobert R Wolfe
May 31, 2011·The Surgical Clinics of North America·Rifat Latifi
Jul 3, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Matthias F OertelDieter-Karten Boeker
Jun 27, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter B Soeters, Robert F Grimble
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G R KlegerP E Ballmer
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gregory J QuinlanTimothy W Evans
Apr 2, 2004·Clinical Physiology and Functional Imaging·Hans BarleJan Wernerman
Sep 26, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Odile MansoorChristiane Obled
Jan 15, 2004·Intensive Care Medicine·Inga TjäderJan Wernerman
May 30, 2006·Clinical Neurology and Neurosurgery·Lekha Pandit, Amit Agrawal
Apr 18, 2015·Critical Care : the Official Journal of the Critical Care Forum·Felix LiebauOlav Rooyackers
Mar 4, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sascha C VerbruggenJohannes B van Goudoever
Mar 30, 2017·PloS One·Gabriel DumitrescuÅke Norberg
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F HammarqvistJ Wernerman
Jan 30, 2004·American Journal of Physiology. Cell Physiology·Stéphane WalrandYves Boirie
Aug 6, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Christelle GuilletStéphane Walrand
Jul 4, 2018·Journal of Clinical Pharmacy and Therapeutics·Brian L Erstad
Jan 25, 2018·Critical Care : the Official Journal of the Critical Care Forum·Lena Gamrin-GripenbergOlav Rooyackers
Jan 20, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jan Erik H BuntJohannes B van Goudoever
Sep 16, 2011·American Journal of Physiology. Endocrinology and Metabolism·Gabriel J WilsonPeter J Garlick
Jul 3, 2015·Physiological Reviews·O FriedrichL Larsson
Feb 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Benoit RuotChristiane Obled
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P J Garlick, M A McNurlan
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Christiane ObledDenis Breuillé
May 17, 2017·Critical Care : the Official Journal of the Critical Care Forum·Olav RooyackersJan Wernerman
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jan WernermanMenaka Sarav

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