PMID: 9641634Jun 26, 1998Paper

Tissue reactions to bacteria-challenged implantable leads with enhanced infection resistance

Journal of Biomedical Materials Research
P B van WachemM J van Luyn

Abstract

Tissue reactions to implantable pacemaker leads were investigated in an early infection model in rabbits. Both standard leads and surface-modified leads were used. The surface modification technique was applied to achieve controlled release of the antibiotic gentamicin. The insulating polyurethane tubing material of the leads was provided with an acrylic acid/acrylamide copolymer surface graft and then loaded with gentamicin. Implantation periods varied from day 4, to week 3 1/2, to week 10. We investigated tissue reactions in the absence of an infectious challenge and also the efficacy of surface-modified leads in preventing infection after challenge with Staphylococcus aureus was evaluated. It was demonstrated that the applied surface modification did not induce adverse effects although during early postimplantation an increase in infiltration of granulocytes and macrophages and wound fluid and fibrin deposition were observed. After bacterial challenge, standard leads were heavily infected at each explantation period, denoted by abscesses, cellular debris, and bacterial colonies. In contrast, little or no infection was observed, either macroscopically or by bacterial cultures, with the surface-modified leads. Microscopy showe...Continue Reading

References

Nov 9, 1991·Lancet·C G BaetenP B Soeters
Apr 1, 1991·Current Opinion in Immunology·T Tsubata, S Nishikawa
Jan 1, 1989·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·A F von Recum, E Barth
May 1, 1989·Antimicrobial Agents and Chemotherapy·G M Dickinson, A L Bisno
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B P GeerdesC G Baeten
Jun 15, 1995·The New England Journal of Medicine·C G BaetenP B Soeters

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Citations

Oct 16, 2009·Biomaterials·Melissa S Ravenscroft-ChangJames J Hickman
Jun 13, 2002·Acta Anaesthesiologica Scandinavica·William E HoffmanZ S Jonjev
Jun 19, 2001·Journal of Biomedical Materials Research·P B van WachemM J van Luyn

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