Tissue resident cells play a dominant role in arteriogenesis and concomitant macrophage accumulation

Circulation Research
Eugen KhmelewskiW Ito

Abstract

Collateral growth is characterized by macrophage accumulation, suggesting an important role of circulating cells. To study origin and function of macrophages during arteriogenesis, we related the extent of macrophage accumulation to vascular proliferation and investigated the fate of fluorescently (CMFDA) labeled blood cells that were injected at the time of femoral artery occlusion. The effect of bone marrow depletion via cyclophosphamide before femoral artery occlusion on collateral proliferation and macrophage accumulation was studied, and we looked for the presence of bone marrow-derived stem cells in the vicinity of growing collateral vessels. Finally, we investigated the arteriogenic effect of macrophage activation via MCP-1 in bone marrow-depleted animals. Maximal macrophage accumulation occurred during the first 3 days after femoral artery occlusion and paralleled the extent of vascular proliferation. Fluorescently labeled leukocytes homed to spleen and wound but they were absent in proliferating collateral arteries during maximal macrophage accumulation. Depletion of circulating cells did neither affect macrophage accumulation nor collateral growth. Staining of monocyte-depleted animals for BrdUrd and ED2, alphaSMA, or...Continue Reading

References

Oct 1, 1977·Nature·P J PolveriniE R Unanue
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Resnick, M A Gimbrone
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y J ShyyS Chien
Oct 10, 1997·The American Journal of Physiology·W D ItoW Schaper
Feb 14, 1998·The Journal of Clinical Investigation·M ArrasW Schaper
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·V GoedeH G Augustin
Aug 10, 2000·Differentiation; Research in Biological Diversity·B Fernandez PujolK Havemann
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sandra HerzogWulf D Ito
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Matthias HeilWolfgang Schaper
Feb 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yong ZhaoEliezer Huberman
Sep 18, 2003·Endothelium : Journal of Endothelial Cell Research·Natalie ObermeyerWulf D Ito
Dec 4, 2003·Science·Irina M ConboyThomas A Rando
Dec 6, 2003·Circulation Research·Tibor ZiegelhoefferWolfgang Schaper
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Johan AarumMats A A Persson
Jan 15, 2004·Seminars in Liver Disease·Markus Grompe

❮ Previous
Next ❯

Citations

Dec 1, 2010·Journal of Cardiovascular Translational Research·Peter J PsaltisRobert D Simari
Apr 4, 2008·The British Journal of Nutrition·Henrike Sell, Juergen Eckel
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jun YuWilliam C Sessa
May 11, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Natalia LandázuriW Robert Taylor
Oct 27, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Paolo MadedduEmilio Hirsch
Aug 3, 2005·The Journal of Clinical Investigation·Eric AckahWilliam C Sessa
Dec 21, 2013·BMC Musculoskeletal Disorders·Claude H CôtéElise Duchesne
Jul 1, 2007·Future Cardiology·Jana Dengler, Milica Radisic
Mar 11, 2009·Blood·Andrea K HorstUwe Ritter
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Anne BouloumiéRudi Busse
Jul 24, 2012·Trends in Molecular Medicine·Andrea la SalaEugenio Stabile
Feb 13, 2010·Microvascular Research·Hsu Chao, Karen K Hirschi
Jan 24, 2007·Journal of Internal Medicine·F S CzepluchJ Waltenberger
Aug 15, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·R Cancello, K Clément
Nov 4, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joshua K Meisner, Richard J Price
Oct 23, 2012·European Journal of Clinical Investigation·Julie FavreAnton J G Horrevoets
Feb 21, 2006·The Journal of Surgical Research·Paula K ShiremanLinda M McManus
Mar 28, 2006·Journal of Cellular and Molecular Medicine·M HeilW Schaper
Mar 7, 2015·Tissue Engineering. Part B, Reviews·Katharina Schmidt-BleekGeorg N Duda
Jul 7, 2015·BioMed Research International·Wulf D ItoThomas Meinertz
Sep 16, 2008·Trends in Cardiovascular Medicine·Sébastien TropAnnie Bourdeau
Apr 10, 2007·Journal of the American College of Cardiology·Christian KupattPeter Boekstegers
Sep 21, 2010·Journal of Molecular and Cellular Cardiology·Evelyn Torsney, Qingbo Xu
Oct 30, 2016·Experimental Gerontology·Stanislava StanojevićMirjana Dimitrijević
Jan 7, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Armin HelischWolfgang Schaper
Apr 11, 2015·Circulation Research·Peter J Psaltis, Robert D Simari
Dec 15, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Vadim TchaikovskiJohannes Waltenberger
Jul 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Huaiping ZhuMing-Hui Zou
Oct 16, 2014·Annals of Biomedical Engineering·Brian J Kwee, David J Mooney
Dec 29, 2019·Journal of Cellular and Molecular Medicine·Xing-Chi LinGuo-Gang Zhang
Oct 27, 2017·Open Medicine·Aldo RoccaBruno Amato
Mar 16, 2017·Stem Cells Translational Medicine·Reinhold J MedinaAlan W Stitt
Jul 28, 2017·Scientific Reports·Yannick van SleenElisabeth Brouwer
Jan 17, 2020·Aging Medicine·Long-Sheng Liao, Yong-Ping Bai
Apr 23, 2020·International Journal of Molecular Sciences·Alexander M GötzeKerstin Troidl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.