Tissue-resident lymphocytes: sentinel of the transformed tissue

Journal for Immunotherapy of Cancer
Saïda Dadi, Ming O Li

Abstract

Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) αβ and TCRγδ lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy.

References

Jan 8, 2011·Science·Eric VivierSophie Ugolini
Apr 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor S CortezMarco Colonna
Aug 13, 2014·The Journal of Experimental Medicine·Theresa L GeigerJoseph C Sun
Oct 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francisco VictorinoEric T Clambey
Oct 17, 2015·Science·Georg GasteigerAlexander Y Rudensky
Nov 17, 2015·Nature Reviews. Immunology·Bana Jabri, Valérie Abadie
May 20, 2016·Nature Immunology·Gabrielle T Belz
Jun 22, 2016·Nature Immunology·Hergen SpitsLewis Lanier
Oct 21, 2016·Nature Immunology·Frédéric VélyEric Vivier
Feb 7, 2017·Nature Medicine·Sarah Q CromePamela S Ohashi

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Citations

May 20, 2018·Nature Immunology·Derk AmsenRene A W van Lier
Aug 15, 2017·Nature Reviews. Immunology·Mikaël EbboEric Vivier
Oct 10, 2018·Frontiers in Immunology·Chun Chou, Ming O Li
May 8, 2021·World Journal of Clinical Oncology·James Wei Tatt TohUmaimainthan Palendira

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