Tissue response to in situ polymerization of a new two-solution bone cement: evaluation in a sheep model

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Matthew J AllenJeremy L Gilbert

Abstract

A two-solution bone cement (2-SC) was evaluated in a non-load bearing sheep model that simulated insertion of a cemented total joint replacement. A commercial powder-liquid bone cement formulation (Palacos R) was used as the control. The systemic response to the two cements was determined by monitoring changes in arterial blood pressure (ABP) and serum concentrations of methyl methacrylate monomer at intervals after insertion of the cement. The short-term tissue response to the two cements was assessed by quantifying histomorphometric parameters of new bone formation at 2, 4, and 12 weeks postsurgery. Intraoperatively, injection and pressurization of bone cement were well tolerated, with no significant changes in ABP in either group and no detectable circulating monomer in any animal. Several interesting trends were identified in the histomorphometry data. In the trabecular specimens, new bone formation immediately adjacent to the cement mantle was apparently suppressed in the first 2 weeks postsurgery, increased dramatically at 4 weeks, and then returned to baseline values by 12 weeks. This pattern was seen with both Palacos and 2-SC. In the cortical specimens, new bone formation was reduced on the endosteal surface when compa...Continue Reading

References

Apr 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·J A CorkillR J Piper
Mar 5, 1999·The Journal of Arthroplasty·D C MarkelS F Markel
Jul 10, 1999·Journal of Biomedical Materials Research·J M HasenwinkelJ L Gilbert
Jul 25, 2000·Journal of Biomedical Materials Research·J L GilbertE P Lautenschlager

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Citations

Jun 26, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Nov 29, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shant AghyarianDanieli C Rodrigues

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