PMID: 11537307Jan 1, 1989

Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
E J AinsworthR J Fry

Abstract

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total...Continue Reading

References

Mar 1, 1979·Cell and Tissue Kinetics·F C Monette, J B DeMello
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Basic
May 1, 1986·International Journal of Radiation Oncology, Biology, Physics·E L TravisI Kiss
Jun 1, 1988·American Journal of Clinical Oncology·H R Withers, H D Thames
Jan 1, 1987·Radiation and Environmental Biophysics·E P CronkiteJ E Bullis
Dec 24, 1987·Nature·J R LetawC H Tsao
Jul 1, 1967·Nature·G E Hanks, E J Ainsworth
Jan 1, 1986·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)· Yang TC-HC A Tobias
Jan 1, 1986·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·E J Ainsworth
Jan 1, 1986·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·M P HaganE J Ainsworth
Jan 1, 1986·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·S B CurtisA Hardy
Jan 1, 1986·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·B V Worgul
Jan 1, 1986·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·T A ParnellJ C Gregory

Citations

Jan 1, 1992·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·M R LandauerJ F Weiss
Jun 25, 2003·Toxicology·Joseph F Weiss, M R Landauer
Jan 1, 1996·IEEE Transactions on Neural Networks·R D Morris, A M Garvin
Jan 1, 1996·IEEE Transactions on Neural Networks·D Sarkar
Jan 1, 1994·IEEE Transactions on Neural Networks·A DelopoulosS Kollias

Related Concepts

Senility
DNA, Double-Stranded
Dose-Response Relationship, Radiation
Trochanter
X-Rays, Nuclear
Hematopoietic System
Neutrons
Radiation Injuries, Experimental
Radiation Protection
Spleen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
J F WeissM R Landauer
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
A B CoxJ T Lett
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
C MedvedovskyE J Ainsworth
The New England Journal of Medicine
Fred A Mettler, George L Voelz
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
M Durante, A Kronenberg
© 2021 Meta ULC. All rights reserved