Tissue responses to the blastospores and hyphae of Candida albicans in the mouse

Journal of Medical Microbiology
Z A Evans

Abstract

Separate groups of mice challenged intravenously with either the blastospore or hyphal forms of the same strain of Candida albicans were examined for comparative mortality rates, organ localisation, and tissue and cellular response to the organisms. Blastospores were more rapidly and consistently fatal to mice than the hyphae. Relatively more hyphal elements than blastospores were initially localised in the lungs but more blastospores than hyphal elements were trapped in the liver. The cells of both forms were more effectively killed in the lungs than in other organs. Blastospores initially found in the kidneys increased rapidly in numbers, but hyphal inocula either grew slowly in the kidneys or were eliminated. After mice were challenged with either hyphae or blastospores the initial inflammatory response in the lungs and liver was predominantly of polymorphonuclear leukocytes, but macrophages were the first inflammatory cells to be seen in kidney sections. Peripheral blood counts showed a leukocytosis in mice of both groups although only blastospores resulted in increased numbers of circulating atypical lymphocytes. The results indicated that lungs may play a more important role than other reticuloendothelial organs in innate...Continue Reading

Citations

May 6, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C S-Y LimP P Chong
Jan 1, 1994·International Journal of Antimicrobial Agents·H Bujdáková, M Múcková
Oct 1, 1986·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M Ghannoum, K Abu Elteen
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Jun 1, 1990·Mycoses·M A Ghannoum, K H Abu-Elteen
Apr 1, 1988·Infection and Immunity·G J Merkel, C L Phelps

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