Tissue restricted expression of two human Frzbs in preadipocytes and pancreas

Biochemical and Biophysical Research Communications
E HuD Brooks

Abstract

Frzb is a newly discovered family of secreted glycoproteins that function to modulate signaling activity of Wnt. Frzb proteins share sequence homology with the extracellular domain of the Wnt receptor (frizzled) and are capable of binding to Wnt. Thus, Frzb functions to antagonize Wnt activity by sequestering Wnt and preventing its binding to the frizzled receptor. Since the initial identification of bovine and human Frzb, several related members of this family have been isolated from rodent and human. In this paper, we describe the cloning and expression of two human frzb homologues termed hFRP-1b and hFRP-2. These human FRPs share significant homology to mouse sFRP-1 and sFRP-2 (55 and 98% identity at amino acid level, respectively). Northern blot experiments revealed that these Frzb homologues have highly restricted tissue distribution. hFRP-1b is exclusively expressed in pancreatic tissue while high levels of hFRP-2 were found in adipose tissue. In addition, low levels of hFRP-2 were also observed in other tissues including heart, pancreas and muscle. Remarkably, FRP-2 is predominantly expressed in un-differentiated preadipocytes in both rodent and man. The expression of FRP-2 is also significantly reduced in fat pads from ...Continue Reading

References

Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R Nusse
Jun 26, 1992·Cell·R Nusse, H E Varmus
Nov 29, 1991·Cell·K R ThomasM R Capecchi
Jan 1, 1995·Annual Review of Biochemistry·O A MacDougald, M D Lane
May 1, 1995·Genes & Development·S YanagawaR Nusse
Jan 1, 1994·Annual Review of Nutrition·P CorneliusM D Lane
Sep 30, 1995·Annals of the New York Academy of Sciences·I BergsteinA M Brown
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
Nov 1, 1996·Medical and Pediatric Oncology·J A Kreidberg
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A RattnerJ Nathans
May 1, 1997·Genome Research·E A StewartD R Cox
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·P W FinchJ S Rubin
Jul 18, 1997·Biochemical and Biophysical Research Communications·S WangM Moos
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·K LinF P Luyten
Dec 6, 1997·Current Opinion in Genetics & Development·T M Loftus, M D Lane
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·H S MelkonyanS R Umansky
Jan 1, 1997·Annual Review of Cell and Developmental Biology·C S HwangM D Lane
Jul 22, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B H HoangR T Ballock

❮ Previous
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Citations

Jan 22, 2000·The Journal of Clinical Investigation·Z AiG I Fishman
Dec 6, 2005·Hematology/oncology Clinics of North America·Evan Pisick, Ravi Salgia
Feb 5, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H DoucasD P Berry
Sep 11, 2004·Protein Expression and Purification·Ramesh A BhatPeter V N Bodine
Nov 30, 2014·Applied Biochemistry and Biotechnology·Archita Ghoshal, Siddhartha Sankar Ghosh
Sep 30, 2016·PloS One·Rachel K CrowleyJeremy W Tomlinson
Dec 10, 2013·Biochimica Et Biophysica Acta·Rohit SuranaAlan Prem Kumar
Feb 6, 2002·Clinics in Plastic Surgery·Saleh M Shenaq, Eser Yuksel
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Steve E Jones, Catherine Jomary
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K MoulinL Casteilla
Aug 5, 2004·Physiological Genomics·Mingming ZhaoDaniel Bernstein
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R Scott HellerPalle Serup
Mar 23, 2006·Pancreas·Hany KayedHelmut Friess
Nov 13, 2001·Oncogene·T Crnogorac-JurcevicN R Lemoine
Oct 29, 2003·The Journal of Biological Chemistry·Xiaozhe Han, Salomon Amar
Oct 25, 2007·Cell·Stephane GestaC Ronald Kahn
Dec 14, 2015·ACS Biomaterials Science & Engineering·Archita GhoshalSiddhartha Sankar Ghosh

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