Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas

European Radiology
S J PriceJonathan H Gillard

Abstract

The inherent invasiveness of malignant cells is a major determinant of the poor prognosis of cerebral gliomas. Diffusion tensor MRI (DTI) can identify white matter abnormalities in gliomas that are not seen on conventional imaging. By breaking down DTI into its isotropic (p) and anisotropic (q) components, we can determine tissue diffusion "signatures". In this study we have characterised these abnormalities in peritumoural white matter tracts. Thirty-five patients with cerebral gliomas and seven normal volunteers were imaged with DTI and T2-weighted sequences at 3 T. Displaced, infiltrated and disrupted white matter tracts were identified using fractional anisotropy (FA) maps and directionally encoded colour maps and characterised using tissue signatures. The diffusion tissue signatures were normal in ROIs where the white matter was displaced. Infiltrated white matter was characterised by an increase in the isotropic component of the tensor (p) and a less marked reduction of the anisotropic component (q). In disrupted white matter tracts, there was a marked reduction in q and increase in p. The direction of water diffusion was grossly abnormal in these cases. Diffusion tissue signatures may be a useful method of assessing occu...Continue Reading

Citations

May 30, 2013·Clinical Neuroradiology·Yuzhen ZhangYuhua Li
Dec 30, 2004·European Radiology·Anne Dumas de la RoqueJean-François Meder
Jan 16, 2007·European Radiology·Stephen J PriceJonathan H Gillard
Jul 25, 2012·Neurology India·Prakash MuthusamiChandrasekharan Kesavadas
May 16, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jatta BerberatSusanne Rogers
Jul 13, 2014·Clinical Neurology and Neurosurgery·Adriaan R E PotgieserRob J M Groen
Jul 8, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nils H UlrichSpyros S Kollias
May 25, 2012·The British Journal of Radiology·S J PriceJ H Gillard
May 25, 2012·The British Journal of Radiology·S J Price, J H Gillard
Jul 4, 2015·Journal of Magnetic Resonance Imaging : JMRI·Stephen J PriceTimothy J Larkin
Jan 11, 2011·Journal of Neuroradiology. Journal De Neuroradiologie·Min Sun BaeEui Jong Kim
Aug 17, 2010·Neuroimaging Clinics of North America·Ajay GuptaAndrei I Holodny
Aug 28, 2009·Journal of Magnetic Resonance Imaging : JMRI·Todd R Jensen, Kathleen M Schmainda
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Jun 24, 2017·World Neurosurgery·Bart R J van DijkenStephen J Price
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Apr 1, 2006·The International Journal of Neuroscience·Werner BengerAnnett Werner
Dec 12, 2007·British Journal of Neurosurgery·Stephen J Price

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