Tissue-sparing application of the newly proposed IASLC/ATS/ERS classification of adenocarcinoma of the lung shows practical diagnostic and prognostic impact

American Journal of Clinical Pathology
William SterlacciAlexandar Tzankov

Abstract

The histologic subtype of non-small cell lung cancer (NSCLC) determines treatment strategies and the need for genetic analyses. Since most NSCLC are diagnosed on small biopsy or cytologic specimens, an accurate but tissue-sparing approach is necessary. To date, consensus for a general diagnostic algorithm is lacking. To test the diagnostic and clinical relevance of the recently published multidisciplinary guidelines by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society, we examined 371 surgically resected NSCLCs brought into tissue microarray format. The antibody panel thyroid transcription factor-1 (TTF-1), p63, cytokeratin (CK)5/6, and CK7 is diagnostic for most cases (>94%). Faint/focal staining for CK7 is negligible for classificatory purposes. Grading adenocarcinomas according to histologic architecture is prognostically significant (median overall survival for well/moderate differentiation, 72.5 months; for poor differentiation, 38.5 months; P = .019). Double stains combining the aforementioned nuclear and membranous markers are highly diagnostic for NSCLC, conserving tumor tissue for subsequent analyses.

References

Mar 1, 1992·Human Pathology·D F Gleason
Feb 7, 2002·The European Respiratory Journal·E BrambillaY Shimosato
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H JohnsonFairooz Kabbinavar
Nov 24, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·N H C AuH L Grimes
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jayne L DennisKarin A Oien
May 2, 2006·Human Pathology·Ricardo CamiloFabíola Del Carlo Bernardi
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Pallav L ShahAndrew G Nicholson
May 12, 2007·Wiener klinische Wochenschrift·Wolfgang HilbeSabine Zöchbauer-Müller
Jul 20, 2007·Current Treatment Options in Oncology·Elwyn Cabebe, Heather Wakelee
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
Aug 30, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Paul DowneyChristian Gulmann
Aug 21, 2009·The New England Journal of Medicine·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Nov 6, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Andres MatosoLi J Wang
Dec 22, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chen MaoQing Chen
Jan 14, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Andrew G NicholsonSanjay Popat
Mar 3, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peh Sun LooKeith M Kerr
Jun 17, 2010·The American Journal of Surgical Pathology·Gabriel SicaAndre L Moreira
Aug 10, 2010·Virchows Archiv : an International Journal of Pathology·Stefano La RosaCarlo Capella
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Nov 26, 2010·The American Journal of Surgical Pathology·Jefferson TerryDiana N Ionescu
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Jan 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akihiko YoshizawaWilliam D Travis
Mar 18, 2011·American Journal of Clinical Pathology·William SterlacciMichael Fiegl
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Koji TsutaHitoshi Tsuda
May 31, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha RekhtmanAndre L Moreira
Nov 11, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giuseppe PelosiMauro Papotti

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Citations

Jan 30, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E CondeF López-Ríos
Aug 1, 2013·Der Pathologe·A WarthW Weichert
Nov 30, 2012·Diagnostic Pathology·Renata Beljan PerakMari Peric
Apr 12, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Timothy D ClayPrudence A Russell
Feb 26, 2014·Seminars in Oncology·Shingo SakashitaMing Sound Tsao
Jan 21, 2014·Human Pathology·Andre L MoreiraNatasha Rekhtman
May 29, 2013·Histopathology·Mercedes Gómez-MoralesMaría Esther Fárez-Vidal
Sep 6, 2013·Journal of Surgical Oncology·Paul E Van SchilWilliam D Travis
Apr 10, 2015·Virchows Archiv : an International Journal of Pathology·Geoffrey PommeAlexandar Tzankov
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William D TravisGregory J Riely
Jul 28, 2013·Virchows Archiv : an International Journal of Pathology·Marta NekulovaBorivoj Vojtesek
May 7, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·William SterlacciAlexandar Tzankov
Jun 7, 2013·International Journal of Surgical Pathology·Giulio RossiMauro Papotti

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