Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat.

Endocrinology
Scott G KurzJames D Shull

Abstract

Ept1, Ept2, Ept6, and Ept9 are quantitative trait loci mapped in crosses between the ACI and Copenhagen (COP) rat strains as genetic determinants of responsiveness of the pituitary gland to estrogens. We have developed four congenic rat strains, each of which carries, on the genetic background of the ACI rat strain, alleles from the COP rat strain that span one of these quantitative trait loci. Relative to the female ACI rats, female ACI.COP-Ept1 rats exhibited reduced responsiveness to 17beta-estradiol (E2) in the pituitary gland, as evidenced by quantification of pituitary mass and circulating prolactin, and in the mammary gland, as evidenced by reduced susceptibility to E2-induced mammary cancer. The ACI.COP-Ept2 rat strain exhibited reduced responsiveness to E2 in the pituitary gland but did not differ from the ACI strain in regard to susceptibility to E2-induced mammary cancer. Interestingly, female Ept2 congenic rats exhibited increased responsiveness to E2 in the thymus, as evidenced by enhanced thymic atrophy. The ACI.COP-Ept6 rat strain exhibited increased responsiveness to E2 in the pituitary gland, which was associated with a qualitative phenotype suggestive of enhanced pituitary vascularization. The ACI.COP-Ept9 rat...Continue Reading

References

Aug 1, 1987·The American Journal of Anatomy·J SchechterR Weiner
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K A Elias, R I Weiner
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·G O Gaufo, M C Diamond
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L WendellJ Gorski
Jun 1, 1997·Mechanisms of Ageing and Development·G DoriaV Covelli
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D L Wendell, J Gorski
Nov 14, 1997·Immunology Today·E WakelandJ Longmate
Aug 11, 1998·Frontiers in Bioscience : a Journal and Virtual Library·D K SarkarR H Reddy
Nov 14, 1998·Developmental Immunology·V De Mello-CoelhoM Dardenne
Sep 26, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D L WendellJ Gorski
Sep 30, 2000·Brain Research·J E DeMariaM E Freeman
Feb 13, 2001·Molecular and Cellular Endocrinology·K A GouldJ Gorski
May 23, 2001·Molecular and Cellular Endocrinology·R V Sclafani, D L Wendell
Dec 4, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Douglas L WendellParker Kelley
Apr 17, 2003·Endocrinology·Nithya KrishnanArthur R Buckley
May 29, 2004·Carcinogenesis·Jyotsna PandeyDouglas L Wendell
Feb 16, 2005·Journal of Neuroimmunology·Paz C CarreñoAgustín G Zapata
Nov 15, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karen A GouldJames D Shull
Nov 15, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jyotsna PandeyDouglas L Wendell
Jan 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jyotsna Pandey, Douglas L Wendell
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karen A GouldJames D Shull
Jul 1, 2006·Frontiers of Hormone Research·Dipak K Sarkar
Sep 19, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·James D ShullKaren A Gould

❮ Previous
Next ❯

Citations

Oct 3, 2008·Breast Cancer Research and Treatment·Rachel L RuhlenEdward R Sauter
Jan 23, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Scott G KurzJames D Shull
Feb 9, 2010·Neuroscience and Biobehavioral Reviews·John K Young
Mar 25, 2015·Endocrine-related Cancer·Kirsten L DennisonJames D Shull
Mar 1, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D Joseph JerryAmy Trentham-Dietz
Sep 13, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emma H WallCory Teuscher
Aug 31, 2014·Cancer Research·Michael J FlisterHoward J Jacob

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Related Papers

Mammalian Genome : Official Journal of the International Mammalian Genome Society
James D ShullKaren A Gould
Brain Research Reviews
Paul MicevychKevin Sinchak
Molecular Interventions
Jason Matthews, Jan-Ake Gustafsson
International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
Y-Q LiangY Ouchi
© 2022 Meta ULC. All rights reserved