Tissue-specific activity of lipoprotein lipase in skeletal muscle regulates the expression of uncoupling protein 3 in transgenic mouse models

The Biochemical Journal
D KratkyR Zechner

Abstract

Uncoupling protein (UCP)-2 and UCP-3 are two recently discovered proteins similar to UCP-1, which regulates thermogenesis in brown adipose tissue (BAT). Whereas UCP-1 expression is restricted to BAT, UCP-2 is widely expressed. UCP-3 is found mainly in skeletal muscle and BAT. A large body of evidence exists that the expression of UCP-2 and UCP-3 in skeletal muscle of mice is regulated by feeding/fasting, and some studies have suggested that this effect might be caused by the changing concentration of plasma non-esterified fatty acids (NEFAs). In an attempt to determine whether the increased import of triacylglycerol-derived NEFAs can also affect UCP expression, we determined the mRNA levels of UCP-1, UCP-2 and UCP-3 in BAT and muscle of induced mutant mouse lines that overexpressed or lacked lipoprotein lipase (LPL) in these tissues. The expression levels of UCP-1 and UCP-2 in BAT and in skeletal and cardiac muscle respectively were not affected by variations in tissue LPL activities. In contrast, UCP-3 mRNA levels were induced 3.4-fold in mice with high levels of LPL in skeletal muscle, and down-regulated in mice that lacked LPL in skeletal muscle. The presence or absence of LPL in BAT had no effect on UCP-3 expression levels....Continue Reading

Citations

Apr 15, 2010·Biochimica Et Biophysica Acta·Eduardo RialM Mar González-Barroso
May 11, 2016·International Journal of Molecular Sciences·Wei ChenDan Xia
Mar 29, 2007·PPAR Research·Francesc VillarroyaMarta Giralt
Apr 28, 2010·Journal of Lipid Research·Maxwell A RubyRonald M Krauss
Jan 12, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Azucena Bermejo-NogalesJaume Pérez-Sánchez
Sep 10, 2003·Journal of Applied Physiology·Yoriko MasudaTohru Fushiki
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pieter de LangeAntonia Lanni
Nov 29, 2013·European Journal of Gastroenterology & Hepatology·Wei LiuRongchun Xing

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