Tissue-specific and imprinted epigenetic modifications of the human NDN gene

Nucleic Acids Research
Jason C Y LauRachel Wevrick

Abstract

Allele-specific DNA methylation, histone acetylation and histone methylation are recognized as epigenetic characteristics of imprinted genes and imprinting centers (ICs). These epigenetic modifications are also used to regulate tissue-specific gene expression. Epigenetic differences between alleles can be significant either in the function of the IC or in the cis-acting effect of the IC on 'target' genes responding to it. We have now examined the epigenetic characteristics of NDN, a target gene of the chromosome 15q11-q13 Prader-Willi Syndrome IC, using sodium bisulfite sequencing to analyze DNA methylation and chromatin immunoprecipitation to analyze histone modifications. We observed a bias towards maternal allele-specific DNA hypermethylation of the promoter CpG island of NDN, independent of tissue-specific transcriptional activity. We also found that NDN lies in a domain of paternal allele-specific histone hyperacetylation that correlates with transcriptional state, and a domain of differential histone H3 lysine 4 di- and tri-methylation that persists independent of transcription. These results suggest that DNA methylation and histone H3 lysine 4 methylation are persistent markers of imprinted gene regulation while histone ...Continue Reading

References

Oct 1, 1995·Genes & Development·C BeardR Jaenisch
Sep 25, 1997·Human Molecular Genetics·H R MacDonald, R Wevrick
Nov 20, 1997·Journal of Cellular Physiology·B Horsthemke
Mar 21, 1998·Developmental Genetics·A M KeohaneB M Turner
Jun 5, 1998·Trends in Genetics : TIG·R D NichollsB Horsthemke
Oct 30, 1998·Biochemical and Biophysical Research Communications·J F HuA R Hoffman
May 14, 1999·Current Opinion in Genetics & Development·C I Brannan, M S Bartolomei
Dec 2, 2000·Nature Genetics·R ShemerA Razin
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C ForsbergE H Bresnick
Mar 29, 2001·Critical Reviews in Eukaryotic Gene Expression·J R MannJ Singer-Sam
May 10, 2001·Current Opinion in Cell Biology·J C Rice, C D Allis
Aug 11, 2001·Science·P A Jones, D Takai
Aug 11, 2001·Science·T Jenuwein, C D Allis
Aug 11, 2001·Science·A C Ferguson-Smith, M A Surani
Aug 11, 2001·Science·W ReikJ Walter
Nov 20, 2001·Nature·J C Rice, C D Allis
May 22, 2002·Nature Genetics·Bernard W FutscherFrederick E Domann
Jun 1, 2002·Nature Genetics·Joseph F Costello, Paula M Vertino
Oct 23, 2003·Human Molecular Genetics·Claire RougeullePhilip Avner
Dec 9, 2003·Nature Cell Biology·Robert SchneiderTony Kouzarides
Feb 21, 2004·Methods in Enzymology·Laura Perez-BurgosThomas Jenuwein

❮ Previous
Next ❯

Citations

Dec 13, 2012·European Journal of Human Genetics : EJHG·Susanne BensReiner Siebert
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Shiri RabinovitzRuth Shemer
Nov 15, 2006·Molecular and Cellular Biology·Yoko Yamasaki-IshizakiTatsuya Kishino
Sep 5, 2008·Annual Review of Genomics and Human Genetics·Ky Sha
Jan 10, 2012·American Journal of Respiratory Cell and Molecular Biology·Youwen YangDonna E Davies
Apr 29, 2010·The Journal of Clinical Investigation·Bermans J IskandarKirk J Hogan
Feb 26, 2010·Epigenetics & Chromatin·Kirsten R McEwen, Anne C Ferguson-Smith
Apr 14, 2012·Journal of Biomedicine & Biotechnology·Shun LiCaode Jiang
Jun 18, 2011·Differentiation; Research in Biological Diversity·Masahiro Kaneda
Jan 26, 2005·Journal of Cellular Biochemistry·Meredith L HanelRachel Wevrick
Oct 30, 2008·Electrophoresis·Tomoko TakamiyaHisato Okuizumi
Jul 25, 2008·The EMBO Journal·Lionel A SanzPhilippe Arnaud
Sep 10, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Shuvomoy BanerjeeErle S Robertson
Apr 1, 2006·Cytogenetic and Genome Research·N MiyoshiM A Surani
Apr 1, 2006·Cytogenetic and Genome Research·T Kishino
Jun 1, 2006·Advances in Genetics·George P RédeiJane D Phillips
Mar 22, 2005·Journal of Cellular Biochemistry·Hidenobu Soejima, Joseph Wagstaff
Jul 16, 2008·American Journal of Medical Genetics. Part a·Bernhard Horsthemke, Joseph Wagstaff
May 24, 2005·Molecular Human Reproduction·A FujimotoD P Wolf
Apr 4, 2013·British Journal of Cancer·L E De FaveriE J Chapman
Jul 8, 2017·BioMed Research International·Krysta Mila CoylePaola Marcato
Aug 3, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kazuaki Yoshikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.