PMID: 9540066Apr 16, 1998Paper

Tissue specific and vitamin D responsive gene expression in bone

Molecular Biology Reports
C P WhiteJ A Eisman

Abstract

Studies of gene expression in bone have adopted a number of molecular approaches that seek to determine those cis and trans-acting factors responsible for the development and physiological regulation of this unique tissue. The majority of studies have been performed in vitro, focussing on the expression of genes such as osteocalcin, bone sialoprotein and type I collagen which demonstrate restricted or altered expression patterns in osteoblasts. These studies have demonstrated a large number of cis and trans acting factors that modulate the tissue specific and vitamin D responsive expression of these genes. These include the response elements and regions mediating basal and vitamin D dependent transcription of these genes as well as some of the transcription factors that bind to these regions and the nucleosomal organisation of these genes within a nuclear framework. In vivo studies, including the introduction of transgenes into transgenic mice, extend these in vitro observations within a physiological context. However, in part due to limitations in each approach, these in vitro and in vivo studies are yet to accurately define all the necessary cis and trans-acting factors required for tissue specific and vitamin D responsive ge...Continue Reading

Citations

Oct 2, 2008·Tissue Engineering. Part B, Reviews·Johan BeneschRui L Reis
Dec 20, 2008·Journal de la Société de biologie·Thierry Thomas, Aline Martin
Mar 20, 2010·BMC Evolutionary Biology·Sylvain MarcelliniMartín Montecino
May 18, 2011·Molecular Biology Reports·Zahra MohammadnejadHoushang Rafatpanah
Jan 13, 2006·Molecular and Cellular Endocrinology·Regina EbertFranz Jakob

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