Tissue-specific effects of chronic dietary protein restriction and gastrostomy on the insulin-like growth factor-I pathway in the liver and colon of adult rats

Metabolism: Clinical and Experimental
Z QuR J Smith

Abstract

Dietary protein restriction decreases plasma concentrations of insulin-like growth factor-I (IGF-I) and reduces IGF-I mRNA levels in the liver. In addition to the actions of systemic IGF-I, locally produced IGF-I is thought to mediate autocrine and paracrine growth effects in the colon. The objectives of the present study were to investigate the IGF-I pathway in the colon and liver of adult rats under conditions of dietary protein restriction, surgical stress, and dietary protein repletion. Two groups of rats were placed on either a 20% or 2% casein diet for 19 days. Two additional groups of rats underwent gastrostomy after a 2% casein diet for 2 weeks, and then were either kept on the 2% casein diet or changed to a 20% casein diet until day 19. Dietary protein restriction reduced plasma concentrations of IGF-I and IGF-binding proteins (IGFBPs) and hepatic IGF-I mRNA content, while increasing colonic IGF-I receptor mRNA. Gastrostomy in protein-depleted animals had no effect on hepatic IGF-I mRNA, but led to a marked increase in colonic IGF-I mRNA levels. Dietary protein repletion resulted in a decrease in colonic IGF-I receptor mRNA. The distinct effects of dietary protein depletion and operative stress on the IGF pathway in th...Continue Reading

References

Feb 1, 1979·Archives of Surgery·J L MullenE F Rosato
Feb 1, 1979·The American Journal of Clinical Nutrition·R L WeinsierC E Butterworth
Aug 31, 1979·World Journal of Surgery·L R Johnson
Jul 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·F MinutoG Giordano
Oct 1, 1993·Gastroenterology·P Singh, N Rubin

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Citations

Apr 14, 2015·BioMed Research International·Varsha P BrahmkhatriHanudatta S Atreya

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