Nov 9, 2018

Tissue-Specific Enrichment Analysis (TSEA) to decode tissue specificity

BioRxiv : the Preprint Server for Biology
Guangsheng PeiPeilin Jia


Diseases and traits are under dynamic tissue-specific regulation. However, heterogeneous tissues are often collected in biomedical studies, which reduce the power in the identification of disease-associated variants and gene expression profiles. We present TSEA, an R package to conduct Tissue-Specific Enrichment Analysis (TSEA) with two built-in reference panels. Statistical methods are developed and implemented for detecting tissue-specific genes and for enrichment test of different forms of query data. Our applications using multi-trait genome-wide association data and cancer expression data showed that TSEA could effectively identify the most relevant tissues for each query trait or sample, providing insights for future studies.

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Mentioned in this Paper

Laboratory Procedures
Regulation of Biological Process
Tissue Specificity
Gene Expression
Statistical Technique
Biomedical Research
EAF2 gene

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