PMID: 11913782Mar 27, 2002Paper

Tissue-specific expression and splicing of the rat polycystic kidney disease 1 gene

DNA Sequence : the Journal of DNA Sequencing and Mapping
H XuE Kleymenova

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic potentially lethal human disorder and the polycystic kidney disease 1 (Pkd1) gene is accounted for 85-90% of these cases. We have obtained rat Pkdl cDNA sequence and characterized splicing of Pkdl RNA transcripts in normal rat tissues. Our sequence data revealed a high conservation of the Pkdl gene between rat and other species and mapped rat Pkdl to chromosome 10 in "tail-to-tail" orientation to the tuberous sclerosis 2 (Tsc2) gene. Pkdl was found ubiquitously expressed in the normal rat tissues and the brain had a complex pattern of exon 12 splicing. A novel splicing variant lacking entire exon 31, which occurs in rat and mouse but not in humans, was also identified. As the rat appears to be a valuable model for investigating polycystic kidney disease, the characterization of the rat Pkdl gene will help facilitate future studies to elucidate the molecular mechanisms of cystogenesis in this animal model.

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Citations

Nov 6, 2009·The Journal of Biological Chemistry·Zhousheng XiaoL Darryl Quarles
Apr 5, 2017·The Journal of Clinical Investigation·Whitney BesseStefan Somlo
Oct 16, 2012·The Journal of Clinical Investigation·Katharina HoppPeter C Harris
Jun 25, 2014·Molecular and Cellular Biology·Almira KurbegovicFeng Qian
Jan 28, 2003·The American Journal of Pathology·Shengli CaiCheryl Lyn Walker
Mar 12, 2011·Biochimica Et Biophysica Acta·Ying-Cai TanHanna Rennert

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