Tissue-specific expression of human terminal deoxynucleotidyl transferase is regulated at the transcriptional level.

Biochemical and Biophysical Research Communications
T Trangas, M S Coleman

Abstract

Transcriptional regulation of expression of the terminal deoxynucleotidyl transferase gene in normal thymus and in differentiation arrested cells was demonstrated by analyzing steady-state levels of TdT RNA as well as the relative transcription rate of the gene. Terminal transferase transcripts were detected only in those cells and tissues that contained antigen and enzyme activity. The relative rates of transcription correlated with levels of mRNA as well as with levels of the protein. These data suggest that expression of this gene in normal and leukemic cells is modulated at the level of transcription.

References

Mar 1, 1989·Trends in Biochemical Sciences·N J Proudfoot
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L K RileyM S Coleman
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H L Sive, R G Roeder
Jul 2, 1971·Biochemical and Biophysical Research Communications·L M Chang
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M S ColemanF J Bollum
Mar 1, 1981·Molecular and Cellular Biology·M GroudineH Weintraub
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J P Kraus, L E Rosenberg

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