Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit

FEBS Letters
T Angelotti, F Hofmann

Abstract

Five different splice variants of mouse alpha2/delta subunit isoforms (alpha2a-e), which arose from various combinations of three alternatively spliced regions, were cloned with a combination of cDNA library screening and RT-PCR. Expression patterns and relative abundance of the various isoforms in mouse tissues were determined with an RNAse protection assay. Skeletal muscle and brain expressed single isoforms, alpha2a and alpha2b, respectively; however, the cardiovascular system expressed all five isoforms. Heart expressed mainly isoforms alpha2c and alpha2d while, in contrast to other species, aorta expressed predominantly alpha2a, the 'skeletal muscle' isoform. Smooth muscle-containing tissues expressed alpha2d and alpha2e. Thus, alpha2/delta isoforms are restricted in their tissue expression, suggesting an important functional role for the differentially spliced variants.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H L KimH Chin
Jan 1, 1991·Annual Review of Cell Biology·M R Green
Feb 1, 1995·Trends in Pharmacological Sciences·G VaradiA Schwartz
Apr 1, 1994·Journal of Cardiovascular Electrophysiology·G Vassort, J Alvarez
Jan 1, 1994·Annual Review of Neuroscience·F HofmannV Flockerzi
Jul 1, 1996·Journal of Neurochemistry·G E GreenD G Drescher

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Citations

Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Danielle Perret, Z David Luo
Mar 1, 2006·Progress in Biophysics and Molecular Biology·Fabien BretteLaurent Sallé
Apr 29, 1998·Trends in Neurosciences·D Walker, M De Waard
Apr 13, 2000·The European Journal of Neuroscience·M HobomN Klugbauer
Jun 29, 2011·Cold Spring Harbor Perspectives in Biology·David C Hill-EubanksMark T Nelson
Jun 21, 2014·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Ricardo FelixArturo Andrade
Nov 5, 2014·Pflügers Archiv : European journal of physiology·Jean-Sebastien RougierPatricia Viard
Dec 1, 2012·Biochimica Et Biophysica Acta·Annette C Dolphin
Mar 30, 2001·The Journal of Biological Chemistry·M PoteserK Groschner
May 5, 2005·Canadian Journal of Physiology and Pharmacology·Kevin S Thorneloe, Mark T Nelson
Jul 27, 2006·Endocrine Reviews·Shao-Nian Yang, Per-Olof Berggren
Jul 19, 2012·Nature Reviews. Neuroscience·Annette C Dolphin
Jan 9, 2013·The Journal of Comparative Neurology·Luis Pérez De Sevilla MüllerNicholas C Brecha
Jan 3, 2014·Physiological Reviews·Franz HofmannJörg W Wegener
Sep 30, 1998·The European Journal of Neuroscience·A PereverzevT Schneider
Oct 18, 2001·The Journal of Biological Chemistry·Y YamadaN Tohse
Apr 18, 2001·Molecular Pharmacology·E MaraisF Hofmann
Nov 8, 2001·American Journal of Physiology. Cell Physiology·K D KeefJ Zhong
Jan 30, 2015·The Journal of Comparative Neurology·Luis Pérez de Sevilla MüllerNicholas Brecha
Jul 25, 2019·International Journal of Molecular Sciences·Arturo AndradeLaura Londrigan
Jun 3, 2021·International Journal of Molecular Sciences·Maartje Westhoff, Rose E Dixon
Nov 13, 2019·ACS Nano·Mohamed Moustafa IbrahimMonica M Jablonski

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