Tissue-Specific Immunopathology in Fatal COVID-19.

American Journal of Respiratory and Critical Care Medicine
David A DorwardChristopher D Lucas

Abstract

Rationale: In life-threatening coronavirus disease (COVID-19), corticosteroids reduce mortality, suggesting that immune responses have a causal role in death. Whether this deleterious inflammation is primarily a direct reaction to the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or an independent immunopathologic process is unknown.Objectives: To determine SARS-CoV-2 organotropism and organ-specific inflammatory responses and the relationships among viral presence, inflammation, and organ injury.Methods: Tissue was acquired from 11 detailed postmortem examinations. SARS-CoV-2 organotropism was mapped by using multiplex PCR and sequencing, with cellular resolution achieved by in situ viral S (spike) protein detection. Histologic evidence of inflammation was quantified from 37 anatomic sites, and the pulmonary immune response was characterized by using multiplex immunofluorescence.Measurements and Main Results: Multiple aberrant immune responses in fatal COVID-19 were found, principally involving the lung and reticuloendothelial system, and these were not clearly topologically associated with the virus. Inflammation and organ dysfunction did not map to the tissue and cellular distribution of SARS-CoV-2...Continue Reading

References

Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jan 7, 2004·The Journal of Experimental Medicine·Brian P O'ConnorRandolph J Noelle
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David M HwangJagdish Butany
Jul 27, 2005·The Journal of Experimental Medicine·Jiang GuAnthony S-Y Leong
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·G D Raj, R C Jones
Jun 17, 2008·Nature Reviews. Microbiology·Hal Drakesmith, Andrew Prentice
Oct 18, 2008·Nature Reviews. Immunology·David S Schneider, Janelle S Ayres
Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Thais MauadPaulo H N Saldiva
Feb 4, 2010·Archives of Pathology & Laboratory Medicine·James R GillJeffery K Taubenberger
Feb 5, 2010·American Journal of Respiratory and Critical Care Medicine·Connie C W HsiaUNKNOWN ATS/ERS Joint Task Force on Quantitative Assessment of Lung Structure
Jun 17, 2010·American Journal of Clinical Pathology·Paul W HarmsJeffrey M Jentzen
Mar 1, 2012·Science·Ruslan MedzhitovMiguel P Soares
Feb 14, 2013·Frontiers in Genetics·Elizabeth J Glass
Aug 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liang YuKwok-Yung Yuen
Jun 29, 2018·PLoS Pathogens·Nicolás Cifuentes-MuñozRoberto Cattaneo
Feb 25, 2020·Emerging Microbes & Infections·Yue-Lin YangYan-Dong Tang
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network
May 14, 2020·Nature Medicine·Mingfeng LiaoZheng Zhang
May 14, 2020·The New England Journal of Medicine·Victor G PuellesTobias B Huber
Jun 10, 2020·Nature Medicine·Aaron J WilkCatherine A Blish
Jun 26, 2020·American Journal of Respiratory and Critical Care Medicine·Oliver J McElvaneyNoel G McElvaney
Jul 12, 2020·Nature Medicine·Aakriti GuptaDonald W Landry
Jul 16, 2020·American Journal of Respiratory and Critical Care Medicine·Brijesh V PatelSujal R Desai
Sep 3, 2020·JAMA : the Journal of the American Medical Association·UNKNOWN WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working GroupJohn C Marshall

❮ Previous
Next ❯

Citations

Dec 4, 2020·American Journal of Respiratory and Critical Care Medicine·Tobias Welte
Feb 10, 2021·Nature·Kara J Mould, William J Janssen
Dec 20, 2020·Scientific Reports·Nicholas ParkinsonSara Clohisey
Feb 16, 2021·Frontiers in Immunology·Thais Fernanda de Campos Fraga-SilvaVânia Luiza Deperon Bonato
Dec 12, 2020·Nature·Erola Pairo-CastineiraJ Kenneth Baillie
Jan 13, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph BalnisAriel Jaitovich
Mar 19, 2021·Expert Review of Respiratory Medicine·Chiara RobbaPatricia R M Rocco
Mar 25, 2021·BMJ : British Medical Journal·Alistair C Darby, Julian A Hiscox
Feb 16, 2021·The Journal of Pathology·Larissa E van EijkHarry van Goor
Apr 1, 2021·Critical Care Explorations·Mahrukh S Rizvi, Alice Gallo De Moraes
Dec 18, 2020·Molecular Cancer Research : MCR·Miran RadaSalvador Macip
Apr 9, 2021·Experimental & Molecular Medicine·Samantha Y Q OngSimon C Biddie
Apr 16, 2021·Circulation Research·Mina K ChungJoseph Loscalzo
Apr 16, 2021·Pathology, Research and Practice·Monica FalleniGaetano Bulfamante
Apr 27, 2021·Trends in Microbiology·Matthew K SigginsPeter J M Openshaw
May 8, 2021·JAMA : the Journal of the American Medical Association·Kimberley DeMerleChristopher W Seymour
Apr 7, 2021·The Journal of Clinical Investigation·Emily R WattsSarah R Walmsley
Mar 12, 2021·Science Immunology·Ryan S ThwaitesUNKNOWN ISARIC4C investigators
May 26, 2021·Current Opinion in Microbiology·Intan Mw DewiFrank L van de Veerdonk
May 18, 2021·Frontiers in Immunology·Xi Zhou, Qing Ye
May 27, 2021·Clinical Epigenetics·Joseph BalnisAriel Jaitovich
Jun 18, 2021·Cell Research·Xiao-Hong YaoXiu-Wu Bian
Jun 19, 2021·The Journal of Antimicrobial Chemotherapy·Julian A HiscoxAndrew Owen
Apr 10, 2021·American Journal of Respiratory and Critical Care Medicine·Sanjay H ChotirmallNitin Seam
Aug 11, 2021·BMC Infectious Diseases·Natasha Marcella VaselliUNKNOWN COVID-LIV Study Group
Aug 10, 2021·World Journal of Virology·Stanislav Vasilev KotsevTsvetelina Velikova
Aug 29, 2021·Viruses·Francisco R CarvalloDiego G Diel
Sep 3, 2021·Intensive Care Medicine·Prasad P VeluAndrew Conway Morris
Sep 28, 2021·International Journal of Immunopathology and Pharmacology·Paul E MarikPierre Kory
Aug 4, 2021·The Journal of Clinical Investigation·Kangyun WuMichael J Holtzman
Jun 6, 2021·Journal of the American Society of Nephrology : JASN·Paulo S CaceresPablo A Ortiz
Aug 11, 2021·American Journal of Respiratory and Critical Care Medicine·Rong BingDavid E Newby
Nov 18, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michelle MøhlenbergRune Hartmann

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Methods Mentioned

BETA
PCR

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