Tissue-specific in vivo inhibition of DNase I gene expression by somatostatin

Biochemical and Biophysical Research Communications
T YasudaK Kishi

Abstract

Administration of somatostatin to rats induced a transient reduction of serum levels of deoxyribonuclease I (DNase I) activity in a dose-dependent manner, followed by a substantial decrease of DNase I activity in the lower gut. Activity in the parotid gland, liver, and kidney did not change. Real-time PCR analysis of the DNase I gene transcript in ileum indicated that the decrease was due to down-regulation of gene expression. Based on these responses, rat tissues expressing DNase I could be classified into two types, somatostatin-sensitive and somatostatin-resistant, and the level of DNase I activity in the lower gut seems to be controlled by somatostatin.

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Citations

Aug 14, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Junko FujiharaHaruo Takeshita
Mar 25, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tamiko NakajimaToshihiro Yasuda
May 2, 2008·Fish & Shellfish Immunology·Tom Christian TonheimRoy Ambli Dalmo
Oct 4, 2007·Biochimica Et Biophysica Acta·Yoshihiko KominatoToshihiro Yasuda
Nov 1, 2008·The International Journal of Biochemistry & Cell Biology·Sebastian LudwigMarkus Napirei
Nov 29, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Junko FujiharaHaruo Takeshita
Jul 22, 2014·European Journal of Medicinal Chemistry·Ana KolarevicAndrija Smelcerovic
Mar 1, 2019·JNCI Cancer Spectrum·Rachel M GolonkaMatam Vijay-Kumar
Sep 24, 2009·Radiation Research·Eugene O ApostolovAlexei G Basnakian
Nov 25, 2004·European Journal of Biochemistry·Toshihiro YasudaKoichiro Kishi

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