Tissue Specific Origin, Development, and Pathological Perspectives of Pericytes

Frontiers in Cardiovascular Medicine
Tomoko Yamazaki, Yoh-Suke Mukouyama

Abstract

Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes play critical roles in maturation and maintenance of vascular branching morphogenesis. In the central nervous system (CNS), pericytes are necessary for the formation and regulation of the blood-brain barrier (BBB) and pericyte deficiency accompanies CNS diseases including multiple sclerosis, diabetic retinopathy, neonatal intraventricular hemorrhage, and neurodegenerative disorders. Despite the importance of pericytes, their developmental origins and phenotypic diversity remain incompletely understood. Pericytes express multiple markers and the origin of pericytes differs by tissue, which may cause difficulty for the identification and understanding of the ontogeny of pericytes. Also, pericytes have the potential to give rise to different tissues in vitro but this is not clear in vivo. These studies indicate that pericytes are heterogeneous in a tissue- and context- dependent manner. This short review focuses on recent studies about identification of pericytes, heterogeneous origin of pericytes during development and in adults, and the differentiation capacity of pericytes, and pericytes in pathological settings.

References

Dec 1, 1992·Cell and Tissue Research·V NehlsD Drenckhahn
Apr 1, 1991·The Journal of Cell Biology·V Nehls, D Drenckhahn
Apr 29, 1998·Annual Review of Physiology·T L CreazzoM L Kirby
Jun 4, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J DohertyA E Canfield
Jan 9, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A TidharM Shani
Sep 29, 2001·Journal of Neurocytology·R BandopadhyayG Allt
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·U OzerdemW B Stallcup
Jan 5, 2002·The Journal of Comparative Neurology·Johannes KornHaymo Kurz
Mar 14, 2002·The American Journal of Pathology·Shunichi MorikawaDonald M McDonald
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hyeseon ChoJohn H Kehrl
May 6, 2003·Circulation Research·Georgina CollettAnn E Canfield
Sep 23, 2003·Journal of Neurocytology·William B Stallcup
Oct 7, 2004·Circulation·C Farrington-RockA E Canfield
Sep 17, 2005·Circulation Research·Annika ArmulikChrister Betsholtz
Oct 11, 2005·Neuro-oncology·Gabriele Bergers, Steven Song
Feb 13, 2007·Nature Cell Biology·Arianna DellavalleGiulio Cossu
Nov 27, 2007·Angiogenesis·Tracy S MitchellYin-Shan Ng
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katie FosterMark Coles
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna M MüllerHans-Reimer Rodewald
Sep 13, 2008·Cell Stem Cell·Mihaela CrisanBruno Péault
Sep 20, 2008·Science·Wei TangJonathan M Graff
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianwen QueBrigid L M Hogan
Nov 14, 2008·Neuron Glia Biology·Xiaoqin ZhuAkiko Nishiyama
Oct 15, 2010·Nature·Annika ArmulikChrister Betsholtz
Feb 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kinji AsahinaHidekazu Tsukamoto
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jifan FengPaul T Sharpe
Jul 9, 2011·Science·Christian GöritzJonas Frisén
Aug 16, 2011·Developmental Cell·Annika ArmulikChrister Betsholtz
Jul 10, 2012·Cell·Nike Julia KrautlerAdriano Aguzzi
Nov 20, 2012·Development, Growth & Differentiation·Emiko YamanishiNoriko Osumi
Nov 21, 2012·Stem Cells·Chien-Wen ChenJohnny Huard
Oct 11, 2013·Nature·Yuya KunisakiPaul S Frenette
Sep 23, 2014·Clinical Science·Alexander BirbrairOsvaldo Delbono
Mar 20, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth E CrouchFiona Doetsch
Dec 5, 2015·Science·Jalal A KhanPaul S Frenette

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Citations

Apr 9, 2019·Journal of Cutaneous Pathology·Veronica Merelo AlcocerKlaus Helm
Mar 12, 2020·International Journal of Molecular Sciences·Hiroyuki YamakawaShinsuke Yuasa
Apr 25, 2019·Vascular Biology·Linda Alex, Nikolaos G Frangogiannis
Aug 7, 2020·International Journal of Molecular Sciences·Carmelina Daniela AnfusoGabriella Lupo
Mar 25, 2020·Nature Immunology·Akshay T Krishnamurty, Shannon J Turley
Aug 20, 2020·Fluids and Barriers of the CNS·David M F FranciscoRémy Bruggmann
Jun 24, 2020·Tissue Engineering. Part B, Reviews·Richard JeskeYan Li
Mar 27, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhitong ZhengJieli Chen
Apr 5, 2020·International Journal of Molecular Sciences·Soo Jin KimJunyeop Lee
Apr 17, 2020·Frontiers in Cardiovascular Medicine·Nicholas W Chavkin, Karen K Hirschi
Jul 12, 2019·Frontiers in Microbiology·María-Angélica Calderón-PeláezJaime E Castellanos
Oct 25, 2020·Acta Neuropathologica·Brittney L BlevinsPeter T Nelson
Oct 27, 2020·PLoS Genetics·Arsheen M RajanPeng Huang
Nov 25, 2020·Tissue Engineering. Part B, Reviews·Elana M MeijerCaroline Cheng
Jan 13, 2021·Cell and Tissue Research·Takehito SatoHiroshi Kiyama
Mar 30, 2021·Frontiers in Cellular Neuroscience·Hannah C Bennett, Yongsoo Kim
Apr 30, 2021·Frontiers in Cardiovascular Medicine·Yoon Kyung Choi, Young-Myeong Kim
Jun 17, 2021·Cell Reports·Laure-Anne TeuwenPeter Carmeliet
Jun 18, 2021·Frontiers in Pharmacology·Feng FengLi Yao
Jun 25, 2021·Immunological Reviews·Rachana N PradhanSören Müller
Jul 20, 2021·Frontiers in Cellular Neuroscience·Louis-Philippe BernierMatilde Balbi
Jul 20, 2021·Progress in Retinal and Eye Research·J BrinksC J F Boon
Jul 14, 2021·The Prostate·Bruno D A SanchesSebastião R Taboga
Jul 25, 2021·International Journal of Molecular Sciences·Ying-Chieh WuŠárka Lehtonen
Jul 25, 2021·The Journal of Clinical Endocrinology and Metabolism·Asumi IesatoCarmelo Nucera
Oct 14, 2021·Molecular Carcinogenesis·Tomoko Yamazaki, Kristina H Young
Dec 23, 2021·Journal of the American Heart Association·Linda AlexNikolaos G Frangogiannis

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Methods Mentioned

BETA
electron microscopy
GTPase
transgenic

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