Tissue-specific regulation of the growth hormone/insulin-like growth factor axis during fasting and re-feeding: Importance of muscle expression of IGF-I and IGF-II mRNA in the tilapia

General and Comparative Endocrinology
Bradley K FoxE G Grau

Abstract

The effects of prolonged nutrient restriction (fasting) and subsequent restoration (re-feeding) on the growth hormone (GH)/insulin-like growth factor (IGF) axis were investigated in the tilapia (Oreochromis mossambicus). Mean weight and specific growth rate declined within 1 week in fasted fish, and remained lower than controls throughout 4 weeks of fasting. Plasma levels of IGF-I were lower than fed controls during 4 weeks of fasting, suggesting a significant catabolic state. Following re-feeding, fasted fish gained weight continuously, but did not attain the weight of fed controls at 8 weeks after re-feeding. Specific growth rate increased above the continuously-fed controls during the first 6 weeks of re-feeding, clearly indicating a compensatory response. Plasma IGF-I levels increased after 1 week of re-feeding and levels were not otherwise different from fed controls. Plasma GH levels were unaffected by either fasting or re-feeding. No consistent effect of fasting or re-feeding was observed on liver expression of GH receptor (GH-R), somatolactin (SL) receptor (SL-R), IGF-I or IGF-II. In contrast, muscle expression of GH-R increased markedly during 4 weeks of fasting, and then declined below control levels upon re-feeding f...Continue Reading

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Citations

Jan 17, 2014·Journal of Applied Genetics·Mahtab YarmohammadiAlireza Abbasalizadeh
Dec 3, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·I M PujanteJ M Mancera
Nov 9, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jason P BrevesE Gordon Grau
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Apr 2, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Benjamin P MoormanAndre P Seale
Dec 9, 2014·General and Comparative Endocrinology·Beth M Cleveland, Gregory M Weber
May 28, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Beth M Cleveland, Gregory M Weber
Feb 25, 2015·General and Comparative Endocrinology·Christine A DuncanHenry B John-Alder
Jun 26, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Camilo PohlenzDelbert M Gatlin
Feb 11, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tadashi Andoh
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Mar 17, 2020·General and Comparative Endocrinology·Cody Petro-SakumaAndre P Seale
May 27, 2020·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Xue LuJian-Fang Gui
Jun 8, 2018·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nicole L HackSean C Lema

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