Tissue-Specific Roles of NKT Cells in Tumor Immunity

Frontiers in Immunology
Masaki Terabe, Jay A Berzofsky

Abstract

NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-classical class-I-like molecule, rather than peptides presented by conventional MHC molecules. Type I NKT cells use a semi-invariant T cell receptor and almost all recognize a common prototype lipid, α-galactosylceramide (α-GalCer). Type II NKT cells are any lipid-specific CD1d-restricted T cells that use other receptors and generally don't recognize α-GalCer. They play important regulatory roles in immunity, including tumor immunity. In contrast to type I NKT cells that most have found to promote antitumor immunity, type II NKT cells suppress tumor immunity and the two subsets cross-regulate each other, forming an immunoregulatory axis. They also can promote other regulatory cells including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and can induce MDSCs to secrete TGF-β, one of the most immunosuppressive cytokines known. In some tumors, both Tregs and type II NKT cells can suppress immunosurveillance, and the balance between these is determined by a type I NKT cell. We have also seen that regulation of tumor immunity can depend on the tissue microenvironment, so the same tumor in the same animal in different...Continue Reading

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Citations

Feb 2, 2019·Nature Reviews. Clinical Oncology·Yosuke TogashiHiroyoshi Nishikawa
Oct 18, 2019·Frontiers in Immunology·Shweta TiwaryMasaki Terabe
Apr 2, 2020·Cancers·Kanako ShimizuAnd Shin-Ichiro Fujii
Nov 21, 2020·Gynecologic Oncology·Yvonne M HoeijmakersJolanda I J M de Vries
Dec 16, 2019·Ageing Research Reviews·Antero Salminen
Jan 29, 2021·Journal of Immunology Research·Nilberto Dias de AraújoAllyson Guimarães Costa
Feb 28, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Mahsa Keshavarz-Fathi, Nima Rezaei
Mar 7, 2021·International Journal of Environmental Research and Public Health·Agnes PeterfalviLaszlo Szereday
Apr 4, 2021·International Journal of Molecular Sciences·Jan KorbeckiIrena Baranowska-Bosiacka
Jul 3, 2021·Cells·Emily E S Brettschneider, Masaki Terabe
Jul 25, 2021·Cancers·Emilie BarsacChristophe Paget
Dec 14, 2021·European Journal of Immunology·Natasja Am KragtenKlaas Pjm van Gisbergen

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