Tissue-Specificity of Gene Expression Diverges Slowly between Orthologs, and Rapidly between Paralogs

PLoS Computational Biology
Nadezda Kryuchkova-Mostacci, Marc Robinson-Rechavi

Abstract

The ortholog conjecture implies that functional similarity between orthologous genes is higher than between paralogs. It has been supported using levels of expression and Gene Ontology term analysis, although the evidence was rather weak and there were also conflicting reports. In this study on 12 species we provide strong evidence of high conservation in tissue-specificity between orthologs, in contrast to low conservation between within-species paralogs. This allows us to shed a new light on the evolution of gene expression patterns. While there have been several studies of the correlation of expression between species, little is known about the evolution of tissue-specificity itself. Ortholog tissue-specificity is strongly conserved between all tetrapod species, with the lowest Pearson correlation between mouse and frog at r = 0.66. Tissue-specificity correlation decreases strongly with divergence time. Paralogs in human show much lower conservation, even for recent Primate-specific paralogs. When both paralogs from ancient whole genome duplication tissue-specific paralogs are tissue-specific, it is often to different tissues, while other tissue-specific paralogs are mostly specific to the same tissue. The same patterns are ...Continue Reading

Associated Proceedings Papers

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Related Concepts

Vertebrates
Neuro-Oncological Ventral Antigen 2
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Benign Neoplasm of Testis
Patterns
LNPEP
Genome
Neoplasm of Uncertain or Unknown Behavior of Testis
Salientia
Tissue Specificity

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