PMID: 2484631Jul 1, 1989Paper

Tissue susceptibility factors in cadmium carcinogenesis. Correlation between cadmium-induction of prostatic tumors in rats and an apparent deficiency of metallothionein

Biological Trace Element Research
M P WaalkesS Rehm

Abstract

Recently, in two separate studies we have observed cadmium (Cd)-induction of prostatic tumors (PT) in rats. Cd (sc or im) at doses nontoxic to the testes markedly increased PT formation (2.5 mumols/kg, sc, 8 PT/29 exposed, 28%; 30 mumols/kg, im, 11/26, 42%; control 14/127, 11%). The administration of zinc (Zn; 1 mmol/kg, sc, at -6, 0 and +18 h) to prevent testicular toxicity and tumors from Cd (30 mumols/kg, sc, 0 h) also resulted in an elevated incidence of PT (8/27, 30%). The nature of the metal-binding proteins in the prostate has not been defined, although metallothionein (MT), a low Mr Cd-binding protein that confers tolerance to Cd, is deficient in other target tissues of Cd carcinogenesis, such as the rat testes. Using a technique that extracts MT from liver, a low-Mr Cd-binding protein was extracted from both ventral (VP) and dorsal prostate (DP) and isolated by gel filtration. In contrast to the two forms of rat MT, reverse phase HPLC of VP and DP extract eluted 1 and 5 forms, respectively. The amino acid compositions of the VP and DP proteins were quite distinct from MT, with much less cys than MT and the presence of residues not found in MT (leu, tyr, phe). Thus Cd-induction of PT appears to be dependent on functiona...Continue Reading

References

Jan 1, 1976·Annals of the New York Academy of Sciences·R A LemenH P Blejer
Oct 15, 1985·The Biochemical Journal·J T Deagen, P D Whanger
Jan 1, 1972·Oncology·O J LucisK Aterman
Jan 1, 1984·The Prostate·W D Flanders
Jun 15, 1984·The Biochemical Journal·M P WaalkesC D Klaassen
Apr 1, 1984·Toxicology and Applied Pharmacology·J W LaskeyJ F Hein
Jan 1, 1982·The Journal of Endocrinology·E A Zylber-HaranI M Spitz
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·S A GUNNW A ANDERSON

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