Tissue topography steers migrating Drosophila border cells.

Science
Wei DaiDenise J Montell

Abstract

Moving cells can sense and respond to physical features of the microenvironment; however, in vivo, the significance of tissue topography is mostly unknown. Here, we used Drosophila border cells, an established model for in vivo cell migration, to study how chemical and physical information influences path selection. Although chemical cues were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopography is also important. Chemoattractants promote predominantly posterior movement, whereas tissue architecture presents orthogonal information, a path of least resistance concentrated near the center of the egg chamber. E-cadherin supplies a permissive haptotactic cue. Our results provide insight into how cells integrate and prioritize topographical, adhesive, and chemoattractant cues to choose one path among many.

References

May 23, 2006·Developmental Biology·Jocelyn A McDonaldDenise J Montell
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Brian E Richardson, Ruth Lehmann
Mar 3, 2010·Annual Review of Biophysics·Kristen F SwaneyPeter N Devreotes
Sep 25, 2012·Nature Reviews. Molecular Cell Biology·Denise J MontellMichelle Starz-Gaiano
May 16, 2013·Development·Roberto Mayor, Eric Theveneau
Apr 22, 2014·Nature Methods·Stephan PreibischPavel Tomancak
May 23, 2014·Cellular and Molecular Life Sciences : CMLS·Yulia ArtemenkoPeter N Devreotes
Jul 16, 2014·Current Opinion in Cell Biology·Danfeng Cai, Denise J Montell
Mar 13, 2015·The EMBO Journal·Jeroen Bussmann, Erez Raz
Nov 3, 2015·Nature Methods·Idse Heemskerk, Sebastian J Streichan
Jan 20, 2016·The Journal of Cell Biology·Elena Scarpa, Roberto Mayor
Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Danfeng CaiDenise J Montell
Jun 9, 2016·Methods in Molecular Biology·Wei Dai, Denise J Montell
Mar 19, 2019·Nature Physics·Jasmin Imran AlsousJӧrn Dunkel
Sep 15, 2019·Nature Communications·Matthew R ZanotelliCynthia A Reinhart-King

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Citations

May 16, 2021·Nature Reviews. Molecular Cell Biology·Shuvasree SenGuptaJames E Bear
Jul 20, 2021·Seminars in Cell & Developmental Biology·Deannah G BlackleyAparna Ratheesh
Sep 5, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maik C Bischoff, Sven Bogdan

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