Abstract
Tissue transglutaminase 2 (TG2) is a recently identified molecule with multifunctional physiological roles. This is the first report of the expression of TG2 in cervical intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma (SCC). For comparison, the expression of p16, a known surrogate biomarker of HPV infection, was evaluated. The expression of nuclear factor kappa B (NF-kappaB), a molecule crucial to inflammation and neoplasia, was also determined to explore its possible linkage with TG2 expression. Twenty cases each with normal cervical histology, CIN1, CIN2, CIN3, and invasive SCC were analyzed for TG2, p16, and NF-kappaB expression by immunohistochemistry. Intergroup differences were analyzed by Friedman ANOVA. Cytoplasmic as well as nuclear TG2 expression was observed in the epithelial cells. As compared to normal controls, CIN1 showed markedly increased cytoplasmic TG2 expression (p = 0.006). In CIN2/3, additional nuclear TG2 expression was seen (p = 0.009 and 0.031, respectively). Marked extracellular stromal upregulation of TG2 was noted in CIN3/SCC versus normal controls (p = 0.054; p = 0.003). There was no relationship of TG2 with either p16 of NF-kappaB expression. Combining TG2 immunoreactivity with...Continue Reading
References
Apr 1, 1999·FEBS Letters·X PengA Lokshin
Feb 23, 2000·The Journal of Cell Biology·S S AkimovA M Belkin
Jun 30, 2000·Virology·V FontaineL Struyk
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Aug 25, 2001·Blood·S S Akimov, A M Belkin
Apr 17, 2002·The Journal of Biological Chemistry·Jason E BoehmRichard A Cerione
May 3, 2002·The Journal of Biological Chemistry·Dimitry SpitkovskyM Lienhard Schmitz
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S Nicholas AgoffLaura A Koutsky
Sep 25, 2003·Human Pathology·Nobuo MasumotoShiro Nozawa
Oct 1, 2003·The EMBO Journal·Ju-Hong JeonIn-Gyu Kim
Sep 24, 2004·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M BrancaK Syrjänen
Feb 3, 2005·The Journal of Infectious Diseases·Rachel L WinerLaura A Koutsky
Aug 23, 2005·Cancer Letters·Philip E CastleCarolyn Y Muller
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Kapil MehtaLingegowda S Mangala
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Evgeny A ZemskovAlexey M Belkin
Oct 27, 2005·Journal of Biochemistry and Molecular Biology·Shishir Shishodia, Bharat B Aggarwal
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M IshikawaS Nozawa
Feb 2, 2006·Oncogene·J F HermanK Mehta
Jun 17, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Suki KangNam Hoon Cho
Jul 5, 2006·Molecular Cancer Therapeutics·Jansina Y FokKapil Mehta
Jul 22, 2006·Advances in Anatomic Pathology·Alexandra N Kalof, Kumarasen Cooper
Aug 18, 2006·Experimental Cell Research·Rima Dardik, Aida Inbal
Sep 5, 2006·Cancer Research·Aman P MannKapil Mehta
Oct 18, 2006·Oncogene·L S MangalaK Mehta
Nov 3, 2006·Cancer Research·Amit VermaKapil Mehta
Nov 14, 2006·Oncogene·L YuanK M Rich
Jun 5, 2007·Pathology, Research and Practice·Işil Z YildizTürkan Küçükali
Citations
Mar 29, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Franca Del NonnoLaura Falasca
Apr 23, 2013·Journal of Cancer Research and Clinical Oncology·Seon-Hyeong LeeSoo-Youl Kim
Jun 15, 2013·The Journal of Pathology·Maria M CaffarelNicholas Coleman
Aug 27, 2016·Amino Acids·Navneet Agnihotri, Kapil Mehta
Aug 26, 2017·BioMedicine·Zsuzsa SzondyGregory J Tsay
Mar 16, 2011·Transplantation·Valeriya ZarkhinMinnie M Sarwal
Jan 30, 2019·Molecular Carcinogenesis·Richard L Eckert
Apr 29, 2021·Neurology. Neuroimmunology and Neuroinflammation·Claudia SestitoJoep Killestein