Tissue transglutaminase-2 promotes gastric cancer progression via the ERK1/2 pathway

Oncotarget
Xiaofeng WangLiping Su

Abstract

Gastric cancer (GC) is one of the most common tumors worldwide and involves extensive local tumor invasion, metastasis, and poor prognosis. Understanding mechanisms regulating progression of GC is necessary for developing effective therapeutic strategies. Tissue transglutaminase-2 (TG2), a multifunctional member of the transglutaminase family, has been shown to be critical for tumor initiation and progression. However, how TG2 promotes the progression of GC is unknown. We report that TG2 was highly expressed in GC tissues and positively associated with depth of tumor invasion and late TNM stage. With gain- and loss-of-function approaches, we observed that TG2 promoted GC cell proliferation, migration, invasion, as well as tumorigenesis and peritoneal metastasis in vivo. These events were associated with the ERK1/2 pathway activation and an ERK1/2 inhibitor (U0126) inhibited cell proliferation, migration, and invasion induced by overexpression of TG2. In summary, TG2 contributes to tumorigenesis and progression of GC by activating the ERK1/2 signaling pathway and is a potential therapeutic target of metastatic gastric cancer.

References

Jan 1, 1984·Molecular and Cellular Biochemistry·L Lorand, S M Conrad
Sep 11, 1999·The International Journal of Biochemistry & Cell Biology·J S Chen, K Mehta
Feb 23, 2000·The Journal of Cell Biology·S S AkimovA M Belkin
May 10, 2003·The Biochemical Journal·Go HasegawaYuji Saito
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Evgeny A ZemskovAlexey M Belkin
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Soo-Youl Kim
Jul 31, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Amit Verma, Kapil Mehta
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amit VermaKapil Mehta
Jun 28, 2008·Amino Acids·Z SarangZ Szondy
Jul 4, 2008·Amino Acids·Angelo Facchiano, Francesco Facchiano
Apr 29, 2009·The Journal of Biological Chemistry·Alessandra ScarpelliniElisabetta A M Verderio
May 26, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hong MuChangyi Chen
Sep 19, 2009·Molecular and Cellular Biochemistry·John M SchmittMonika A Davare
Feb 11, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Ke-Ming XieDa-Jin Li
Feb 19, 2011·Molecular Cancer Therapeutics·May KhannaSamy Meroueh
Jun 29, 2011·Current Molecular Medicine·N RucciA Angelucci
Sep 10, 2011·The FEBS Journal·Alexey M Belkin
Dec 12, 2012·Breast Cancer Research and Treatment·Kevin D Brown
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Jan 31, 2014·International Journal of Cancer. Journal International Du Cancer·Santosh KumarKapil Mehta

❮ Previous
Next ❯

Citations

May 30, 2020·Experimental & Molecular Medicine·Sung-Yup ChoCharles Lee
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chengbo YuLanjuan Li
Aug 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shun-Le LiZong-Zheng Ji

❮ Previous
Next ❯

Datasets Mentioned

BETA
GES-1

Methods Mentioned

BETA
surgical resection
chips
PCR
Protein Assay

Software Mentioned

GLOBOCAN
SPSS

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.