PMID: 2116507Aug 1, 1990Paper

Tissue trimethyllysine biosynthesis and carnitine content in pregnant and lactating rats fed a lysine-limiting diet

The Journal of Nutrition
A T Davis

Abstract

Previous studies have indicated that carnitine biosynthesis is primarily regulated by the availability of trimethyllysine. The present study investigated the rate of trimethyllysine biosynthesis during pregnancy in rats fed a lysine-restricted diet. Pregnant Sprague-Dawley rats were fed ad libitum a crystalline amino acid diet (18% amino acids) containing either 1.44% or 0.36% lysine. Food intakes were not significantly different between the two groups, either during 19 d of gestation or 12 d of lactation (p greater than 0.05). Trimethyllysine content and synthetic rates were not significantly different between the treatment groups for any of the five tissues tested at either of the two time points. Tissue carnitine content was not consistently affected by dietary lysine content. Liver carnitine content was significantly higher in control rat pups at 12 d of lactation than in pups in the lysine-deficient group. Pups in both groups had peptide-linked trimethyllysine levels in skeletal muscle that were 46% of those seen in the control adults. However, previous reports of higher protein turnover in the neonate would indicate that trimethyllysine is not limiting at this age. Under these experimental conditions, carnitine biosynthes...Continue Reading

Citations

May 1, 1996·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A LohningerR Marz
Jan 1, 1995·Journal of Perinatal Medicine·M SchoderbeckA Lohninger
Jun 5, 1995·American Journal of Medical Genetics·M L Katz, A N Siakotos
Apr 5, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kalliopi I PappaEugene Koumantakis
Jul 1, 1995·Journal of Pediatric Surgery·D N LinzM M Ziegler

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