Titania nanopores with dual micro-/nano-topography for selective cellular bioactivity

Materials Science & Engineering. C, Materials for Biological Applications
Karan GulatiSašo Ivanovski

Abstract

This letter describes a simple surface modification strategy based on a single-step electrochemical anodization towards generating dual micro- and nano-rough horizontally-aligned TiO2 nanopores on the surface of clinically utilized micro-grooved titanium implants. Primary macrophages, osteoblasts and fibroblasts were cultured on the nano-engineered implants, and it was demonstrated that the modified surfaces selectively reduced the proliferation of macrophages (immunomodulation), while augmenting the activity of osteoblasts (osseo-integration) and fibroblasts (soft-tissue integration). Additionally, the mechanically robust nanopores also stimulated osteoblast and fibroblast adhesion, attachment and alignment along the direction of the pores/grooves, while macrophages remained oval-shaped and sparsely distributed. This study for the first time reports the use of cost-effectively prepared nano-engineered titanium surface via anodization, with aligned multi-scale micro/nano features for selective cellular bioactivity, without the use of any therapeutics.

Citations

Feb 1, 2020·Journal of Biomaterials Applications·Shang GaoSu Chen
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bing RenYong Huang
Jan 15, 2021·Acta Biomaterialia·Tianqi GuoSašo Ivanovski
Feb 4, 2021·Microsystems & Nanoengineering·An'an ShengHuanyu Cheng
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Karan GulatiSašo Ivanovski
Oct 1, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Daniel Martinez-MarquezSašo Ivanovski
Feb 12, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Priya Mohindra, Tejal A Desai
Mar 27, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anjana JayasreeKaran Gulati
Jun 16, 2021·ACS Biomaterials Science & Engineering·Divya ChopraSašo Ivanovski
Jul 28, 2021·ACS Biomaterials Science & Engineering·Karan GulatiSašo Ivanovski
Sep 10, 2018·ACS Biomaterials Science & Engineering·Karan GulatiSašo Ivanovski

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